Abstract: Objective To evaluate the efficacy and tolerance of monochromatic excimer light (MEL) 308 nm in the treatment of vitiligo.Methods Seventy-seven patients were enrolled in the prospective and open clinical study.Two-hundred and one lesions were subjected to local phototherapy of MEL 308-nm once a week for 3 to 6 months.Results Of these lesions,86.6% obtained repigmentation at different degrees.The repigmentation was more obvious in lesions on the head,face,neck and trunk than in those on the limbs or extremities.Moreover,patients with generalized and segmental vitiligo got a better improvement than patients with other types of vitiligo.Conclusion MEL 308-nm is effective in the treatment of vitiligo without obvious adverse effects.

Key words: Vitiligo, Monochromatic excimer light, Efficacy