Chinese Journal of Dermatology ›› 2020, Vol. 53 ›› Issue (12): 1026-1028.doi: 10.35541/cjd.20190641

• Reviews • Previous Articles     Next Articles

Role of skin-resident memory T cells in inflammatory response in vitiligo

Lu Haojie, Song Xiuzu   

  1. Department of Dermatology, The Third People′s Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China
  • Received:2019-06-04 Revised:2020-02-26 Online:2020-12-15 Published:2020-12-02
  • Contact: Song Xiuzu E-mail:songxiuzu@sina.com.cn
  • Supported by:
    National Natural Science Foundation of China (81872517); Zhejiang Basic Public Welfare Research Project(LGF18H110001); Hangzhou Science and Technology Planning Project(20130733Q24)

Abstract: 【Abstract】 Tissue-resident memory T(TRM)cells are derived from stimulated primary T cells and reside in peripheral tissues, mediating rapid immune responses of the host to similar stimuli. Although this immune response helps protect the host against local infections, long-term residence of TRM cells in the skin can lead to repeated attacks of autoimmune-related skin diseases such as vitiligo. This review summarizes the relationship between TRM cells and vitiligo as well as potential therapeutic targets.

Key words: Vitiligo, T-lymphocyte subsets, Recurrence, Tissue-resident memory T cells