白癜风的外科治疗进展

doi:10.35541/cjd.20190091

Abstract

Abstract: 【Abstract】 Vitiligo is a common depigmented disease, and currently there is no specific treatment. In clinical practice, common treatments include topical or oral drugs, phototherapy and surgery. Surgical interventions mainly include tissue and cellular grafting. Tissue grafting techniques include punch/mini grafting, split-thickness skin grafting, epidermal suction blister grafting, and cellular grafting techniques include cultured and non-cultured autologous melanocyte grafting. These surgical treatments are safe and effective for patients with stable, localized vitiligo or those irresponsive to other therapies.

Key words: Vitiligo, Surgical procedures, operative, Tissue transplantation, Cellular transplantation, Transplantation, autologous

Wang Wei, Xiao Shichu. Surgical interventions for vitiligo[J]. Chinese Journal of Dermatology, 2020, 53(5): 384-386.doi:10.35541/cjd.20190091

References ［24］

［1］	Mohammad TF, Hamzavi IH. Surgical therapies for vitiligo［J］. Dermatol Clin, 2017,35（2）:193⁃203. doi: 10.1016/j.det.2016.11. 009.
［2］	Hirobe T, Enami H. Excellent color⁃matched repigmentation of human vitiligo can be obtained by mini⁃punch grafting using a machine in combination with ultraviolet therapy［J］. Dermatologica Sinica, 2018, 36（4）:203⁃206. doi:10.1016/j.dsi. 2018.01.004.
［3］	Sun X, Qian G, Wu Y, et al. Transplantation of autologous minigrafts for the treatment of stable vitiligo［J］. J Dermatolog Treat, 2012,23（2）:122⁃127. doi: 10.3109/09546634.2010.507 703.
［4］	Tsuchiyama K, Watabe A, Sadayasu A, et al. Successful treatment of segmental vitiligo in children with the combination of 1⁃mm minigrafts and phototherapy［J］. Dermatology, 2016,232（2）:237⁃241. doi: 10.1159/000442666.
［5］	Gupta S, Gupta S, Kumar A. The hypodermic needle as a dermabrading device for recipient area preparation for skin grafting in vitiligo［J］. J Am Acad Dermatol, 2015,72（4）:e105⁃e106. doi: 10.1016/j.jaad.2015.01.017.
［6］	Tam J, Wang Y, Farinelli WA, et al. Fractional skin harvesting: autologous skin grafting without donor⁃site morbidity［J］. Plast Reconstr Surg Glob Open, 2013,1（6）:e47. doi: 10.1097/GOX. 0b013e3182a85a36.
［7］	Pripotnev S, Papp A. Split thickness skin graft meshing ratio indications and common practices［J］. Burns, 2017,43（8）:1775⁃1781. doi: 10.1016/j.burns.2017.04.024.
［8］	Fuller DA. Split thickness skin graft to lower leg［J］. J Orthop Trauma, 2016,30 Suppl 2:S34. doi: 10.1097/BOT.000000000000 0605.
［9］	Bekara F, Herlin C, Ayestaray B, et al. Suction drain⁃assisted split⁃thickness skin grafting: a simple procedure to improve skin graft take［J］. Plast Reconstr Surg, 2015,135（1）:240e⁃1e. doi: 10.1097/PRS.0000000000000782.
［10］	Mulekar SV, Isedeh P. Surgical interventions for vitiligo: an evidence⁃based review［J］. Br J Dermatol, 2013,169 Suppl 3:57⁃66. doi: 10.1111/bjd.12532.
［11］	Purschke M, Asrani FA, Sabir SA, et al. Novel methods for generating fractional epidermal micrografts［J］. Br J Dermatol, 2015,172（4）:1021⁃1028. doi: 10.1111/bjd.13468.
［12］	李金勇,王晓云,刘超, 等. 不同取皮法对白癜风自体移植表皮角质形成细胞的影响［J］. 中华皮肤科杂志, 2011,44（6）:396⁃398.
［13］	Gupta S, Kumar A, Mahendra A, et al. A minimally invasive, scarless technique of donor tissue harvesting for noncultured epidermal cell suspension transplantation in vitiligo［J］. J Am Acad Dermatol, 2015,73（6）:e213⁃e215. doi: 10.1016/j.jaad.2015. 07.037.
［14］	Gupta S, Sahni K, Tembhre MK, et al. A novel point⁃of⁃care in vivo technique for preparation of epidermal cell suspension for transplantation in vitiligo［J］. J Am Acad Dermatol, 2015,72（2）:e65⁃e66. doi: 10.1016/j.jaad.2014.10.042.
［15］	Gan EY, Kong YL, Tan WD, et al. Twelve⁃month and sixty⁃month outcomes of noncultured cellular grafting for vitiligo［J］. J Am Acad Dermatol, 2016,75（3）:564⁃571. doi: 10.1016/j.jaad. 2016.04.007.
［16］	O′Neill TB, Rawlins J, Rea S, et al. Treatment of a large congenital melanocytic nevus with dermabrasion and autologous cell suspension （ReCELL®）: a case report［J］. J Plast Reconstr Aesthet Surg, 2011,64（12）:1672⁃1676. doi: 10.1016/j.bjps.2011.05.016.
［17］	Wood FM, Giles N, Stevenson A, et al. Characterisation of the cell suspension harvested from the dermal epidermal junction using a ReCell® kit［J］. Burns, 2012,38（1）:44⁃51. doi: 10. 1016/j.burns.2011.03.001.
［18］	Verma G, Varkhande SR, Kar HK, et al. Evaluation of repigmentation with cultured melanocyte transplantation （CMT） compared with non⁃cultured epidermal cell transplantation in vitiligo at 12th week reveals better repigmentation with CMT［J］. J Invest Dermatol, 2015,135（10）:2533⁃2535. doi: 10.1038/jid. 2015.178.
［19］	Hong WS, Hu DN, Qian GP, et al. Ratio of size of recipient and donor areas in treatment of vitiligo by autologous cultured melanocyte transplantation［J］. Br J Dermatol, 2011,165（3）:520⁃525. doi: 10.1111/j.1365⁃2133.2011.10398.x.
［20］	金嵘, 洪为松, 许爱娥. 自体培养黑素细胞移植治疗生殖器部位白癜风［J］. 中华皮肤科杂志, 2019,52（6）:429⁃430. doi: 10.3760/cma.j.issn.0412-4030.2019.06.011
［21］	Yao L, Zhong SX, Hu DN, et al. Repigmentation of leukotrichia in vitiligo with transplantation of cultured autologous melanocytes［J］. Int J Dermatol, 2014,53（8）:1016⁃1018. doi: 10.1111/j.1365⁃4632.2012.05674.x.
［22］	Ezz⁃Eldawla R, Abu EM, Saied SM, et al. A comparative study between suction blistering graft, mini punch graft, and hair follicle transplant in treatment of patients with stable vitiligo［J］. J Dermatolog Treat, 2019,30（5）:492⁃497. doi: 10.1080/09546 634.2018.1528329.
［23］	Shih S. Platelet⁃rich plasma: potential role in combined therapy for vitiligo［J］. Dermatol Ther, 2019,32（1）:e12773. doi: 10.1111/dth.12773.
［24］	Kim H, Kang JN, Hwang SH, et al. Fibrin glue fixation for suction blister epidermal grafting in two patients with stable vitiligo［J］. Ann Dermatol, 2014,26（6）:751⁃754. doi: 10.5021/ad.2014.26.6.751.

[1]	Lei Jiehao, Hong Weisong, Lin Fuquan, Hu Wenting, Xu Ai′e. In vitro culture of melanocytes from segmental vitiligo-like nevus depigmentosus lesions and its clinical significance [J]. Chinese Journal of Dermatology, 2022, 55(9): 798-802.
[2]	Li Baizhang, Kang Pan, Zhang Xiaoying, Zhu Guannan, Li Shuli, Li Chunying. Construction and validation of a risk prediction model for diabetes mellitus in patients with vitiligo [J]. Chinese Journal of Dermatology, 2022, 55(7): 576-582.
[3]	Jian Zhe, Zhang Jia. Research progress and thinking in mouse models of vitiligo-like depigmentation [J]. Chinese Journal of Dermatology, 2022, 55(7): 622-628.
[4]	Ainiwaer·Talifu, Xiong Cheng, Refuhati·Saimaiti, Yusufu·Maitinuer, Tuerxun·Wufuer, Akenmujiang·Aierken, Julaiti·Abuduwayiti, Maimaitiaili·Kade. Screening and analysis of differentially expressed genes in vitiligo using bioinformatics methods [J]. Chinese Journal of Dermatology, 2022, 55(5): 421-425.
[5]	Fu Chao, Wu Jiaona, Lang Wenchao, Gao Fei, Niu Guiye, Bian Peiwen, Gao Minhong, Si Xiaoqing, Xin Linlin. Role of dermoscopy in assessing vitiligo activity [J]. Chinese Journal of Dermatology, 2022, 55(3): 268-271.
[6]	Zha Zhen, Solang Quzong, Ciren Yangji, Bai Yang, Deji Yangzong, Zhang Wei, . Clinical characteristics of 527 patients of Tibetan nationality with vitiligo [J]. Chinese Journal of Dermatology, 2022, 0(2): 20210940-e20210940.
[7]	Zeng Rui, Xu Xiulian. Narrow-band ultraviolet B phototherapy combined with other therapies for the treatment of vitiligo [J]. Chinese Journal of Dermatology, 2022, 0(1): 20210010-e20210010.
[8]	Luan Chao, Hu Yu, Chen Kun, Zhang Jiaan, Gu Heng, Zhang Ronglin, Zhang Xiaohua, Tian Panpan, Zhu Yan, Zhuang Chen, Huang Dan, Ju Mei. Efficacy and safety of 308-nm SQ light-emitting diode light and 308-nm excimer light in the treatment of facial vitiligo: a retrospective study [J]. Chinese Journal of Dermatology, 2022, 55(1): 16-19.
[9]	Chen Yi, Song Xiuzu. Role of transient receptor potential channels in melanocytes and their related diseases [J]. Chinese Journal of Dermatology, 2022, 0(1): 20200958-e20200958.
[10]	Ying Jieya, Xiang Wenzhong, Song Xiuzu. Metabolic syndrome and skin diseases [J]. Chinese Journal of Dermatology, 2021, 54(7): 642-645.
[11]	Guo Lifang, Ge Yiping, Yang Yin, Lin Tong. Establishment and evaluation of an artificial intelligence model for the diagnosis of facial vitiligo [J]. Chinese Journal of Dermatology, 2021, 54(7): 586-589.
[12]	Liao Zhikai, Lei Tiechi. Therapeutic trauma-induced repigmentation of vitiligo lesions: mechanisms and relevant clinical studies [J]. Chinese Journal of Dermatology, 2021, 54(3): 267-269.
[13]	Xie Bo, Wei Xiaodong, Xu Ai′e, Lin Fuquan, Zhou Miaoni. Efficacy of systemic glucocorticoid treatment and its related factors in patients with progressive vitiligo [J]. Chinese Journal of Dermatology, 2021, 54(2): 139-144.
[14]	Pigmentary Disorder Group, Combination of Traditional and Western Medicine Dermatology. Consensus on the diagnosis and treatment of vitiligo （2021 version） [J]. Chinese Journal of Dermatology, 2021, 54(2): 105-109.
[15]	Zhou Miaoni, Lin Fuquan, Zhu Yiping, Jin Rong, Sheng Anqi, Xu Wen, Xu Ai′e . Role of folliculin in interferon-γ-mediated apoptosis of and chemokine secretion by melanocytes [J]. Chinese Journal of Dermatology, 2021, 54(10): 878-883.

Surgical interventions for vitiligo

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［24］

Related Articles 15

Metrics

Comments

Recommended 10