Abstract: Objective To determine the efficacy and safety of the 308nm excimer laser in the treatment of vitiligo.Methods A Self-controlled study was conducted.The vitiligo lesions in stable stage of 75 patients were treated twice a week by the 308 nm excimer laser for 6 weeks.The efficacy and factors related to efficacy were evaluated 3 days later after the final treatment.Results No improvement was observed in any of the untreated vitiligo lesions.However,of the treated lesions,6 completely disappeared,33 obtained significant improvement,30 moderate improvement,6 no improvement.The effective rate was 92.0% and the markedly effective rate was 52.0%.The lesions on the face and neck had a better response to the treatment than those on the trunk or limbs,and the latter responded better than those on the joints of extremities.Conclusion The 308 nm excimer laser is safe and effective in treatment of vitiligo in stable stage and the efficacy is related to the anatomic sites.

Key words: Vitiligo, Excimer laser, Efficacy