皮脂腺脂质的合成及相关免疫学效应

doi:10.35541/cjd.20230405

中华皮肤科杂志 ›› 2024, e20230405.doi: 10.35541/cjd.20230405

皮脂腺脂质的合成及相关免疫学效应

程淑琼钟美珍郑思齐曾抗黄晓雯

南方医科大学南方医院皮肤科，广州 510515

收稿日期:2023-07-17 修回日期:2024-05-03 发布日期:2024-09-29
通讯作者: 黄晓雯 E-mail:huangxw@smu.edu.cn
基金资助:
广州市科技计划（202201011376）

Synthesis and related immunological effects of sebum lipids

Cheng Shuqiong, Zhong Meizhen, Zheng Siqi, Zeng Kang, Huang Xiaowen

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

Received:2023-07-17 Revised:2024-05-03 Published:2024-09-29
Contact: Huang Xiaowen E-mail:huangxw@smu.edu.cn
Supported by:
Guangzhou Science and Technology Planning Project（202201011376）

摘要/Abstract

摘要： 【摘要】皮脂腺脂质是皮脂的主要成分，其合成受多种因素的共同影响。皮脂腺脂质具有多种免疫学效应，在皮肤免疫中发挥重要作用，并且其含量和成分的变化会影响炎症性皮肤病的发生发展。本文综述影响皮脂腺脂质合成的主要因素及其免疫学效应，以期为炎症性皮肤病的临床治疗提供思路。

关键词: 皮脂腺, 脂类, 免疫调节, 胆固醇调节元件结合蛋白质1, 过氧化物酶体增殖物激活受体, 神经肽类, 内源性大麻酚类, 炎症性皮肤病

Abstract: 【Abstract】 Sebaceous gland lipids are the main components of sebum, and their synthesis is affected by a variety of factors. Sebaceous gland lipids possess multiple immunological effects, playing a crucial role in skin immunity, and changes in their content and composition can affect the occurrence and development of inflammatory skin diseases. This review summarizes the main factors affecting the synthesis of sebaceous gland lipids and their immunological effects, aiming to provide insights for the clinical treatment of inflammatory skin diseases.

Key words: Sebaceous glands, Lipids, Immunomodulation, Sterol regulatory element binding protein 1, Peroxisome proliferator-activated receptors, Neuropeptides, Endocannabinoids, Inflammatory dermatosis

程淑琼钟美珍郑思齐曾抗黄晓雯. 皮脂腺脂质的合成及相关免疫学效应[J]. 中华皮肤科杂志, 2024,e20230405. doi:10.35541/cjd.20230405

Cheng Shuqiong, Zhong Meizhen, Zheng Siqi, Zeng Kang, Huang Xiaowen. Synthesis and related immunological effects of sebum lipids[J]. Chinese Journal of Dermatology,2024,e20230405. doi:10.35541/cjd.20230405

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皮脂腺脂质的合成及相关免疫学效应

Synthesis and related immunological effects of sebum lipids

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