自主神经在特应性皮炎免疫失调中的作用

doi:10.35541/cjd.20210298

中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (4): 362-365.doi: 10.35541/cjd.20210298

自主神经在特应性皮炎免疫失调中的作用

余愫郁天泽李巍

复旦大学附属华山医院皮肤科，上海 200040

收稿日期:2021-04-18 修回日期:2021-06-29 发布日期:2022-04-01
通讯作者: 李巍 E-mail:liweiderma@163.com
基金资助:
国家自然科学基金（81972939）

Role of the autonomic nervous system in immune imbalance in atopic dermatitis

Yu Su, Yu Tianze, Li Wei

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China

Received:2021-04-18 Revised:2021-06-29 Published:2022-04-01
Contact: Li Wei E-mail:liweiderma@163.com
Supported by:
National Natural Science Foundation of China（81972939）

摘要/Abstract

摘要： 【摘要】皮肤含有丰富的神经末梢，其中自主神经与皮肤角质形成细胞、免疫细胞间均存在密切的交互联系，对皮肤生理功能具有重要的调控作用。特应性皮炎患者皮损自主神经密度减少，同时伴有泌汗障碍等自主神经功能异常。通过恢复自主神经功能，可改善特应性皮炎症状。本文综述皮肤自主神经的结构和生理功能、特应性皮炎患者自主神经功能异常的表现以及可能的治疗策略。

关键词: 皮炎, 特应性, 自主神经系统, 神经免疫调节, 屏障免疫

Abstract: 【Abstract】 The skin is rich in nerve terminals, among which autonomic nerves closely interacted with keratinocytes and immune cells. The autonomic nerves are critical to skin physiological function. Patients with atopic dermatitis exhibit reduced autonomic innervation, accompanied by autonomic nerve dysfunction such as sweating disorder. Restoration of autonomic neurological function can ameliorate atopic dermatitis. This review summarizes the anatomy and physiological function of skin autonomic nerves, autonomic neurological abnormalities in atopic dermatitis, and possible therapeutic strategies.

Key words: Dermatitis, atopic, Autonomic nervous system, Neuroimmunomodulation, Barrier immunity

余愫郁天泽李巍. 自主神经在特应性皮炎免疫失调中的作用[J]. 中华皮肤科杂志, 2022,55(4):362-365. doi:10.35541/cjd.20210298

Yu Su, Yu Tianze, Li Wei. Role of the autonomic nervous system in immune imbalance in atopic dermatitis[J]. Chinese Journal of Dermatology, 2022, 55(4): 362-365.doi:10.35541/cjd.20210298

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自主神经在特应性皮炎免疫失调中的作用

Role of the autonomic nervous system in immune imbalance in atopic dermatitis

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