中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (5): 449-451.doi: 10.35541/cjd.20200110

• 综述 • 上一篇    下一篇

肥大细胞在变应性接触性皮炎发病中的作用进展

孙晓丽1,李邻峰2   

  1. 1北京怀柔医院皮肤科，北京  101400；2首都医科大学附属北京友谊医院皮肤科，北京  100050
  • 收稿日期:2020-02-13 修回日期:2020-08-10 发布日期:2022-04-29
  • 通讯作者: 李邻峰 E-mail:zoonli@sina.com

Role of mast cells in the pathogenesis of allergic contact dermatitis

Sun Xiaoli1, Li Linfeng2   

  1. 1Department of Dermatology, Beijing Huairou Hospital, Beijing 101400, China; 2Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Received:2020-02-13 Revised:2020-08-10 Published:2022-04-29
  • Contact: Li Linfeng E-mail:zoonli@sina.com

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摘要： 【摘要】 变应性接触性皮炎（ACD）是由接触性变应原引起的T细胞介导的炎症性皮肤病，肥大细胞在其中的作用尚存在争议。在致敏阶段，肥大细胞通过释放炎症因子促进中性粒细胞募集发挥促炎作用，通过刺激或抑制树突细胞的迁移影响致敏过程。在激发阶段，肥大细胞促进非变应原特异性炎症；增强中度，但是抑制重度及慢性ACD的变应原所致特异性炎症。除IgE-Fc受体I-组胺途径外，肥大细胞Mas相关G蛋白偶联受体B2/X2激活后，释放类胰蛋白酶，介导非组胺依赖性瘙痒，可能成为治疗ACD的新靶点。

关键词: 皮炎, 变应性接触性, 肥大细胞, 变应原, 致敏

Abstract: 【Abstract】 Allergic contact dermatitis （ACD） is a T cell-mediated inflammatory skin disease induced by contact allergens. The role of mast cells in ACD remains controversial. In the sensitization phase, mast cells play a pro-inflammatory role by releasing inflammatory cytokines to promote recruitment of neutrophils, and affect the sensitization process by stimulating or inhibiting the migration of dendritic cells. During the elicitation phase, mast cells promote non-allergen-specific inflammation, and enhance allergen-specific inflammation in moderate ACD, but inhibit allergen-specific inflammation in severe and chronic ACD. In addition to the IgE-Fcε receptor I-histamine pathway, Mas-related G-protein coupled receptor B2/X2 （MrgprB2/X2） can mediate the activation of mast cells, leading to the release of tryptase to drive non-histaminergic itch, and may serve as a new target for the treatment of ACD.

Key words: Dermatitis, allergic contact, Mast cells, Allergens, Sensitization