中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (4): 365-369.doi: 10.35541/cjd.20210333
覃诗纯 李梦杰 陆晓云 肖风丽
收稿日期:
2021-04-23
修回日期:
2021-10-27
发布日期:
2022-04-01
通讯作者:
肖风丽
E-mail:xiaofengli@126.com
基金资助:
Qin Shichun, Li Mengjie, Lu Xiaoyun, Xiao Fengli
Received:
2021-04-23
Revised:
2021-10-27
Published:
2022-04-01
Contact:
Xiao Fengli
E-mail:xiaofengli@126.com
Supported by:
摘要: 【摘要】 随着基因芯片技术、RNA测序技术等转录组学技术发展,特应性皮炎(AD)发病中重要的相关影响因素逐渐被揭示,如不同T辅助(Th)细胞的亚型以及其他免疫相关细胞如巨噬细胞、朗格汉斯细胞;在AD的瘙痒及皮肤屏障破坏方面,相关免疫细胞如Th2细胞及角质形成细胞等所释放白细胞介素4、白细胞介素13、聚丝蛋白、兜甲蛋白等活性物质的异常变化起着主要作用。同时,转录组技术已被用于分析患者治疗前后转录谱的变化从而对患者的病情和治疗效果进行评估等。本文总结近年来在AD转录组学方面的研究进展。
覃诗纯 李梦杰 陆晓云 肖风丽. 特应性皮炎的转录组学研究进展[J]. 中华皮肤科杂志, 2022,55(4):365-369. doi:10.35541/cjd.20210333
Qin Shichun, Li Mengjie, Lu Xiaoyun, Xiao Fengli. Transcriptomics in atopic dermatitis[J]. Chinese Journal of Dermatology, 2022, 55(4): 365-369.doi:10.35541/cjd.20210333
[1] | Brown SJ, Elias MS, Bradley M. Genetics in atopic dermatitis: historical perspective and future prospects[J]. Acta Derm Venereol, 2020,100(12):adv00163. doi: 10.2340/00015555⁃3513. |
[2] | Mucha S, Baurecht H, Novak N, et al. Protein⁃coding variants contribute to the risk of atopic dermatitis and skin⁃specific gene expression[J]. J Allergy Clin Immunol, 2020,145(4):1208⁃1218. doi: 10.1016/j.jaci.2019.10.030. |
[3] | Besin G, Yousefi M, Saba I, et al. Dok⁃1 overexpression promotes development of γδ natural killer T cells[J]. Eur J Immunol, 2012,42(9):2491⁃2504. doi: 10.1002/eji.201242421 |
[4] | Chiricozzi A, Maurelli M, Peris K, et al. Targeting IL⁃4 for the treatment of atopic dermatitis[J]. Immunotargets Ther, 2020,9:151⁃156. doi: 10.2147/ITT.S260370. |
[5] | Majewska A, Gajewska M, Dembele K, et al. Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis[J]. BMC Vet Res, 2016,12(1):174. doi: 10.1186/s12917⁃016⁃0805⁃6. |
[6] | Castro G, Liu X, Ngo K, et al. RORγt and RORα signature genes in human Th17 cells[J]. PLoS One, 2017,12(8):e0181868. doi: 10.1371/journal.pone.0181868. |
[7] | Ha Y, Lee WH, Jeong J, et al. Pyropia yezoensis extract suppresses IFN⁃gamma⁃ and TNF⁃alpha⁃induced proinflammatory chemokine production in HaCaT cells via the down⁃regulation of NF⁃κB[J]. Nutrients, 2020,12(5):1238. doi: 10.3390/nu12051238. |
[8] | Shin KO, Ha DH, Kim JO, et al. Exosomes from human adipose tissue⁃derived mesenchymal stem cells promote epidermal barrier repair by inducing de Novo synthesis of ceramides in atopic dermatitis[J]. Cells, 2020,9(3):680. doi: 10.3390/cells 9030680. |
[9] | Nedoszytko B, Reszka E, Gutowska⁃Owsiak D, et al. Genetic and epigenetic aspects of atopic dermatitis[J]. Int J Mol Sci, 2020,21(18):6484. doi: 10.3390/ijms21186484. |
[10] | Fujii M. Current understanding of pathophysiological mechanisms of atopic dermatitis: interactions among skin barrier dysfunction, immune abnormalities and pruritus[J]. Biol Pharm Bull, 2020,43(1):12⁃19. doi: 10.1248/bpb.b19⁃00088. |
[11] | Freudenberg JM, Olivry T, Mayhew DN, et al. The comparison of skin transcriptomes confirms canine atopic dermatitis is a natural homologue to the human disease[J]. J Invest Dermatol, 2019,139(4):968⁃971. doi: 10.1016/j.jid.2018.10.018. |
[12] | Pavel AB, Renert⁃Yuval Y, Wu J, et al. Tape strips from early⁃onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin[J]. Allergy, 2021,76(1):314⁃325. doi: 10. 1111/all.14490. |
[13] | Torres T, Ferreira EO, Gonçalo M, et al. Update on atopic dermatitis[J]. Acta Med Port, 2019,32(9):606⁃613. doi: 10. 20344/amp.11963. |
[14] | Lee YS, Han SB, Ham HJ, et al. IL⁃32γ suppressed atopic dermatitis through inhibition of miR⁃205 expression via inactivation of nuclear factor⁃kappa B[J]. J Allergy Clin Immunol, 2020,146(1):156⁃168. doi: 10.1016/j.jaci.2019.12.905. |
[15] | Dyjack N, Goleva E, Rios C, et al. Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2⁃high atopic dermatitis disease endotype[J]. J Allergy Clin Immunol, 2018,141(4):1298⁃1309. doi: 10.1016/j.jaci.2017.10. 046. |
[16] | Furue M. Regulation of filaggrin, loricrin, and involucrin by IL⁃4, IL⁃13, IL⁃17A, IL⁃22, AHR, and NRF2: pathogenic implications in atopic dermatitis[J]. Int J Mol Sci, 2020,21(15):5382. doi: 10.3390/ijms21155382. |
[17] | Bieber T. Interleukin⁃13: targeting an underestimated cytokine in atopic dermatitis[J]. Allergy, 2020,75(1):54⁃62. doi: 10.1111/ all.13954. |
[18] | Rajesh A, Wise L, Hibma M. The role of Langerhans cells in pathologies of the skin[J]. Immunol Cell Biol, 2019,97(8):700⁃713. doi: 10.1111/imcb.12253. |
[19] | Huang L, Li GH, Yu Q, et al. Smad2/4 signaling pathway is critical for epidermal langerhans cell repopulation under inflammatory condition but not required for their homeostasis at steady state[J]. Front Immunol, 2020,11:912. doi: 10.3389/fimmu.2020.00912. |
[20] | Brunner PM, Israel A, Leonard A, et al. Distinct transcriptomic profiles of early⁃onset atopic dermatitis in blood and skin of pediatric patients[J]. Ann Allergy Asthma Immunol, 2019,122(3):318⁃330.e3. doi: 10.1016/j.anai.2018.11.025. |
[21] | Novak H, Müller A, Harrer N, et al. CCL23 expression is induced by IL⁃4 in a STAT6⁃dependent fashion[J]. J Immunol, 2007,178(7):4335⁃4341. doi: 10.4049/jimmunol.178.7.4335. |
[22] | Devos M, Mogilenko DA, Fleury S, et al. Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis[J]. J Invest Dermatol, 2019,139(1):135⁃145. doi: 10.1016/j.jid.2018.06.191. |
[23] | Yuan W, Chen Y, Zhou Y, et al. Formononetin attenuates atopic dermatitis by upregulating A20 expression via activation of G protein⁃coupled estrogen receptor[J]. J Ethnopharmacol, 2021,266:113397. doi: 10.1016/j.jep.2020.113397. |
[24] | Nattkemper LA, Tey HL, Valdes⁃Rodriguez R, et al. The genetics of chronic itch: gene expression in the skin of patients with atopic dermatitis and psoriasis with severe itch[J]. J Invest Dermatol, 2018,138(6):1311⁃1317. doi: 10.1016/j.jid.2017.12. 029. |
[25] | Tham EH, Dyjack N, Kim BE, et al. Expression and function of the ectopic olfactory receptor OR10G7 in patients with atopic dermatitis[J]. J Allergy Clin Immunol, 2019,143(5):1838⁃1848.e4. doi: 10.1016/j.jaci.2018.11.004. |
[26] | Denda M. Newly discovered olfactory receptors in epidermal keratinocytes are associated with proliferation, migration, and re⁃epithelialization of keratinocytes[J]. J Invest Dermatol, 2014,134(11):2677⁃2679. doi: 10.1038/jid.2014.229. |
[27] | Aida Maranduca M, Liliana Hurjui L, Constantin Branisteanu D, et al. Skin ⁃ a vast organ with immunological function (Review)[J]. Exp Ther Med, 2020,20(1):18⁃23. doi: 10.3892/etm.2020. 8619. |
[28] | Spidale NA, Malhotra N, Frascoli M, et al. Neonatal⁃derived IL⁃17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis[J]. Elife, 2020,9:e51188. doi: 10.7554/eLife.51188. |
[29] | Mizutani N, Sae⁃Wong C, Kangsanant S, et al. Thymic stromal lymphopoietin⁃induced interleukin⁃17A is involved in the development of IgE⁃mediated atopic dermatitis⁃like skin lesions in mice[J]. Immunology, 2015,146(4):568⁃581. doi: 10.1111/imm.12528. |
[30] | Mirshafiey A, Simhag A, El Rouby NM, et al. T⁃helper 22 cells as a new player in chronic inflammatory skin disorders[J]. Int J Dermatol, 2015,54(8):880⁃888. doi: 10.1111/ijd.12883. |
[31] | He H, Suryawanshi H, Morozov P, et al. Single⁃cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis[J]. J Allergy Clin Immunol, 2020,145(6):1615⁃1628. doi: 10.1016/j.jaci.2020.01.042. |
[32] | Kennedy K, Heimall J, Spergel JM. Advances in atopic dermatitis in 2017[J]. J Allergy Clin Immunol, 2018,142(6):1740⁃1747. doi: 10.1016/j.jaci.2018.10.012. |
[33] | Guttman⁃Yassky E, Bissonnette R, Ungar B, et al. Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis[J]. J Allergy Clin Immunol, 2019,143(1):155⁃172. doi: 10.1016/j.jaci.2018.08.022. |
[34] | Ko KC, Tominaga M, Kamata Y, et al. Possible antipruritic mechanism of cyclosporine a in atopic dermatitis[J]. Acta Derm Venereol, 2016,96(5):624⁃629. doi: 10.2340/00015555⁃2318. |
[35] | Möbus L, Rodriguez E, Harder I, et al. Atopic dermatitis displays stable and dynamic skin transcriptome signatures[J]. J Allergy Clin Immunol, 2021,147(1):213⁃223. doi: 10.1016/j.jaci.2020. 06.012. |
[36] | Lossius AH, Berents TL, Saetre F, et al. Early transcriptional changes after UVB treatment in atopic dermatitis include inverse regulation of IL⁃36γ and IL⁃37[J]. Exp Dermatol, 2021,30(2):249⁃261. doi: 10.1111/exd.14217. |
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