环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子信号通路在银屑病发病中的作用

doi:10.35541/cjd.20230394

中华皮肤科杂志 ›› 2024, e20230394.doi: 10.35541/cjd.20230394

环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子信号通路在银屑病发病中的作用

吴玉冰¹ 王晓宇² 安彬祎³ 吴莹莹³ 桑红^1，2，3 孔庆涛^1，2，3

¹南京中医药大学金陵临床医学院皮肤科，南京 210002；²南京大学医学院附属金陵医院（东部战区总医院）皮肤科，南京 210002；³南京医科大学金陵临床医学院皮肤科，南京 210002

收稿日期:2023-07-05 修回日期:2023-10-27 发布日期:2024-02-06
通讯作者: 桑红；孔庆涛 E-mail:sanghong@nju.edu.cn; njukqt@163.com
基金资助:
江苏省皮肤病学创新团队（CXTDA2017038）

Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes signaling pathway in the occurrence of psoriasis

Wu Yubing¹, Wang Xiaoyu², An Binyi³, Wu Yingying³, Sang Hong^1,2,3, Kong Qingtao^1,2,3

¹Department of Dermatology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210002, China; ²Department of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China; ³Department of Dermatology, Affiliated Jinling Hospital of Nanjing Medical University, Nanjing 210002, China

Received:2023-07-05 Revised:2023-10-27 Published:2024-02-06
Contact: Sang Hong; Kong Qingtao E-mail:sanghong@nju.edu.cn; njukqt@163.com
Supported by:
Jiangsu Dermatology Innovation Team（CXTDA2017038）

摘要/Abstract

摘要： 【摘要】银屑病的发病机制涉及先天性和适应性免疫系统。环鸟苷酸-腺苷酸合成酶（cGAS）-干扰素基因刺激因子（STING）信号通路能识别致病DNA，触发先天性免疫反应。本文综述了cGAS-STING信号通路在银屑病发病机制中的作用和相关靶向药物的研究进展，为后续研究提供参考。

关键词: 银屑病, 干扰素Ⅰ型, cGAS-STING信号通路

Abstract: 【Abstract】 The pathogenesis of psoriasis involves both the innate and adaptive immune systems. The cyclic guanosine monophosphate-adenosine monophosphate synthase （cGAS）-stimulator of interferon genes （STING） signaling pathway can identify disease-causing DNA and trigger innate immune responses. This review summarizes the role of the cGAS-STING signaling pathway in the pathogenesis of psoriasis and the research progress on related targeted drugs, providing a reference for further studies.

Key words: Psoriasis, Interferon type I, cGAS-STING signaling pathway

吴玉冰王晓宇安彬祎吴莹莹桑红孔庆涛. 环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子信号通路在银屑病发病中的作用[J]. 中华皮肤科杂志, 2024,e20230394. doi:10.35541/cjd.20230394

Wu Yubing, Wang Xiaoyu, An Binyi, Wu Yingying, Sang Hong, Kong Qingtao, . Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes signaling pathway in the occurrence of psoriasis[J]. Chinese Journal of Dermatology,2024,e20230394. doi:10.35541/cjd.20230394

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环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子信号通路在银屑病发病中的作用

Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes signaling pathway in the occurrence of psoriasis

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