中华皮肤科杂志 ›› 2024, e20230241.doi: 10.35541/cjd.20230241
刘莹莹,邓丹琪
收稿日期:2023-04-27
修回日期:2024-01-13
发布日期:2024-05-17
通讯作者:
邓丹琪
E-mail:danqid128@sina.com
Liu Yingying, Deng Danqi
Received:2023-04-27
Revised:2024-01-13
Published:2024-05-17
Contact:
Deng Danqi
E-mail:danqid128@sina.com
摘要: 【摘要】 近年来,皮肤肿瘤的发病率不断上升且患者日趋年轻化,对人类健康造成很大威胁,但其发病机制和病因仍未完全明确。多项研究表明,皮肤微生物组与皮肤肿瘤的发生、发展密切相关。本文就皮肤肿瘤的皮肤微生态失调,对皮肤屏障和免疫系统的影响及微生态治疗进行综述,以期为皮肤肿瘤的早期诊断及治疗提供新思路。
刘莹莹 邓丹琪. 皮肤微生物与皮肤肿瘤相关性的研究进展[J]. 中华皮肤科杂志, 2024,e20230241. doi:10.35541/cjd.20230241
Liu Yingying, Deng Danqi. Correlations between skin microbiome and skin tumors[J]. Chinese Journal of Dermatology,2024,e20230241. doi:10.35541/cjd.20230241
| [1] | Richardson BN, Lin J, Buchwald ZS, et al. Skin microbiome and treatment⁃related skin toxicities in patients with cancer: a mini⁃review[J]. Front Oncol, 2022,12:924849. doi: 10.3389/fonc. 2022.924849. |
| [2] | Kapoor B, Gulati M, Rani P, et al. Psoriasis: interplay between dysbiosis and host immune system[J]. Autoimmun Rev, 2022,21(11):103169. doi: 10.1016/j.autrev.2022.103169. |
| [3] | Schneider AM, Nolan ZT, Banerjee K, et al. Evolution of the facial skin microbiome during puberty in normal and acne skin[J]. J Eur Acad Dermatol Venereol, 2023,37(1):166⁃175. doi: 10.1111/jdv.18616. |
| [4] | Gao YW, Yao X, Yang XY. Application of bioengineered bacteria in allergic diseases[J]. Int J Dermatol Venerol, 2023,6(1):43⁃48. doi: 10.1097/JD9.0000000000000242. |
| [5] | Łyko M, Jankowska⁃Konsur A. The skin microbiome in cutaneous T⁃cell lymphomas (CTCL)⁃a narrative review[J]. Pathogens, 2022,11(8):935. doi: 10.3390/pathogens11080935. |
| [6] | Jost M, Wehkamp U. The skin microbiome and influencing elements in cutaneous T⁃cell lymphomas[J]. Cancers (Basel), 2022,14(5):1324. doi: 10.3390/cancers14051324. |
| [7] | 郑娜娜, 曾荣, 陶盈凯, 等. 环状RNA与皮肤肿瘤相关性研究进展[J]. 中华皮肤科杂志, 2023,e20210893. doi: 10.35541/cjd.20210893. |
| [8] | Squarzanti DF, Zavattaro E, Pizzimenti S, et al. Non⁃melanoma skin cancer: news from microbiota research[J]. Crit Rev Microbiol, 2020,46(4):433⁃449. doi: 10.1080/1040841X.2020. 1794792. |
| [9] | Parida S, Sharma D. The microbiome and cancer: creating friendly neighborhoods and removing the foes within[J]. Cancer Res, 2021,81(4):790⁃800. doi: 10.1158/0008⁃5472.CAN⁃20⁃2629. |
| [10] | Kennedy MS, Chang EB. The microbiome: composition and locations[J]. Prog Mol Biol Transl Sci, 2020,176:1⁃42. doi: 10. 1016/bs.pmbts.2020.08.013. |
| [11] | Luna PC. Skin microbiome as years go by[J]. Am J Clin Dermatol, 2020,21(Suppl 1):12⁃17. doi: 10.1007/s40257⁃020⁃00549⁃5. |
| [12] | Byrd AL, Belkaid Y, Segre JA. The human skin microbiome[J]. Nat Rev Microbiol, 2018,16(3):143⁃155. doi: 10.1038/nrmicro. 2017.157. |
| [13] | 闫慧敏, 姜薇. 人类皮肤微生物群和皮肤疾病[J]. 中国皮肤性病学杂志, 2015,29(12):1292⁃1294. doi: 10.13735/j.cjdv. 1001⁃7089.201412052. |
| [14] | Wood D, Lachner N, Tan JM, et al. A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes[J]. mBio, 2018,9(5):e01432⁃18. doi: 10.1128/mBio.01432⁃18. |
| [15] | Blümel E, Munir Ahmad S, Nastasi C, et al. Staphylococcus aureus alpha⁃toxin inhibits CD8+ T cell⁃mediated killing of cancer cells in cutaneous T⁃cell lymphoma[J]. Oncoimmunology, 2020,9(1):1751561. doi: 10.1080/2162402X.2020.1751561. |
| [16] | Nakatsuji T, Chen TH, Butcher AM, et al. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia[J]. Sci Adv, 2018,4(2):eaao4502. doi: 10.1126/sciadv.aao4502. |
| [17] | Mizuhashi S, Kajihara I, Sawamura S, et al. Skin microbiome in acral melanoma: Corynebacterium is associated with advanced melanoma[J]. J Dermatol, 2021,48(1):e15⁃e16. doi: 10.1111/1346⁃8138.15633. |
| [18] | Mrázek J, Mekadim C, Kučerová P, et al. Melanoma⁃related changes in skin microbiome[J]. Folia Microbiol (Praha), 2019,64(3):435⁃442. doi: 10.1007/s12223⁃018⁃00670⁃3. |
| [19] | Kumar P, Brazel D, DeRogatis J, et al. The cure from within? A review of the microbiome and diet in melanoma[J]. Cancer Metastasis Rev, 2022,41(2):261⁃280. doi: 10.1007/s10555⁃022⁃10029⁃3. |
| [20] | Gluud M, Pallesen E, Buus TB, et al. Malignant T cells induce skin barrier defects through cytokine⁃mediated JAK/STAT signaling in cutaneous T⁃cell lymphoma[J]. Blood, 2023,141(2):180⁃193. doi: 10.1182/blood.2022016690. |
| [21] | Edslev SM, Agner T, Andersen PS. Skin microbiome in atopic dermatitis[J]. Acta Derm Venereol, 2020,100(12):adv00164. doi: 10.2340/00015555⁃3514. |
| [22] | Bosman ES, Albert AY, Lui H, et al. Skin exposure to narrow band ultraviolet (UVB) light modulates the human intestinal microbiome[J]. Front Microbiol, 2019,10:2410. doi: 10.3389/fmicb.2019.02410. |
| [23] | Wang X,Koffi PF,English OF,et al. Staphylococcus aureus extracellular vesicles: a story of toxicity and the stress of 2020 [J]. Toxins (Basel), 2021,13(2):75. doi: 10.3390/toxins13020075. |
| [24] | Krueger A,Mohamed A,Kolka CM,et al. Skin cancer⁃associated S. aureus strains can induce DNA damage in human keratinocytes by downregulating DNA repair and promoting oxidative stress[J]. Cancers (Basel), 2022,14(9):2143. doi:10.3390/cancers14092143. |
| [25] | Quintero⁃Fabián S, Arreola R, Becerril⁃Villanueva E, et al. Role of matrix metalloproteinases in angiogenesis and cancer[J]. Front Oncol, 2019,9:1370. doi: 10.3389/fonc.2019.01370. |
| [26] | Nauroy P, Nyström A. Kallikreins: Essential epidermal messengers for regulation of the skin microenvironment during homeostasis, repair and disease[J]. Matrix Biol Plus, 2020,6⁃7:100019. doi: 10.1016/j.mbplus.2019.100019. |
| [27] | Krueger A, Zaugg J, Chisholm S, et al. Secreted toxins from Staphylococcus aureus strains isolated from keratinocyte skin cancers mediate pro⁃tumorigenic inflammatory responses in the skin[J]. Front Microbiol, 2021,12:789042. doi: 10.3389/fmicb. 2021.789042. |
| [28] | Duan T,Du Y,Xing C,et al. Toll⁃like receptor signaling and its role in cell⁃mediated immunity[J]. Front Immunol, 2022,13:812774. doi:10.3389/fimmu.2022.812774. |
| [29] | Blohm⁃Mangone K, Burkett NB, Tahsin S, et al. Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV⁃induced skin tumorigenesis in SKH⁃1 mice[J]. Cancer Prev Res (Phila), 2018,11(5):265⁃278. doi: 10.1158/1940⁃6207.CAPR⁃17⁃0349. |
| [30] | Mann JE, Ludwig ML, Kulkarni A, et al. Microbe⁃mediated activation of Toll⁃like receptor 2 drives PDL1 expression in HNSCC[J]. Cancers (Basel), 2021,13(19):4782. doi: 10.3390/cancers13194782. |
| [31] | Kiatsurayanon C, Ogawa H, Niyonsaba F. The role of host defense peptide human β⁃defensins in the maintenance of skin barriers[J]. Curr Pharm Des, 2018,24(10):1092⁃1099. doi: 10. 2174/1381612824666180327164445. |
| [32] | Madhusudhan N,Pausan MR,Halwachs B,et al. Molecular profiling of keratinocyte skin tumors links Staphylococcus aureus overabundance and increased human β⁃defensin⁃2 expression to growth promotion of squamous cell carcinoma [J]. Cancers (Basel), 2020,12(3):541. doi: 10.3390/cancers12030541. |
| [33] | Nakagawa S, Matsumoto M, Katayama Y, et al. Staphylococcus aureus virulent PSMα peptides induce keratinocyte alarmin release to orchestrate IL⁃17⁃dependent skin inflammation[J]. Cell Host Microbe, 2017,22(5):667⁃677.e5. doi: 10.1016/j.chom. 2017.10.008. |
| [34] | Ridaura VK, Bouladoux N, Claesen J, et al. Contextual control of skin immunity and inflammation by Corynebacterium[J]. J Exp Med, 2018,215(3):785⁃799. doi: 10.1084/jem.20171079. |
| [35] | Sakamoto R, Kajihara I, Mijiddorj T, et al. Existence of Staphylococcus aureus correlates with the progression of extramammary Paget′s disease: potential involvement of interleukin⁃17 and M2⁃like macrophage polarization[J]. Eur J Dermatol, 2021,31(1):48⁃54. doi: 10.1684/ejd.2021.3972. |
| [36] | Willerslev⁃Olsen A, Krejsgaard T, Lindahl LM, et al. Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL⁃17 expression in cutaneous T⁃cell lymphoma[J]. Blood, 2016,127(10):1287⁃1296. doi: 10.1182/blood⁃2015⁃08⁃662353. |
| [37] | Willerslev⁃Olsen A, Gjerdrum L, Lindahl LM, et al. Staphylococcus aureus induces signal transducer and activator of transcription 5⁃dependent miR⁃155 expression in cutaneous T⁃cell lymphoma[J]. J Invest Dermatol, 2021,141(10):2449⁃2458. doi: 10.1016/j.jid.2021.01.038. |
| [38] | Lindahl LM, Willerslev⁃Olsen A, Gjerdrum L, et al. Antibiotics inhibit tumor and disease activity in cutaneous T⁃cell lymphoma[J]. Blood, 2019,134(13):1072⁃1083. doi: 10.1182/blood.2018 888107. |
| [39] | Blümel E, Willerslev⁃Olsen A, Gluud M, et al. Staphylococcal alpha⁃toxin tilts the balance between malignant and non⁃malignant CD4+ T cells in cutaneous T⁃cell lymphoma[J]. Oncoimmunology, 2019,8(11):e1641387. doi: 10.1080/2162402X. 2019.1641387. |
| [40] | Glatthardt T,Campos JC de M,Chamon RC,et al. Small molecules produced by commensal Staphylococcus epidermidis disrupt formation of biofilms by staphylococcus aureus [J]. Appl Environ Microbiol, 2020,86(5):e02539⁃19. doi:10.1128/AEM. 02539⁃19. |
| [41] | Wang Z, Choi JE, Wu CC, et al. Skin commensal bacteria Staphylococcus epidermidis promote survival of melanocytes bearing UVB⁃induced DNA damage, while bacteria Propionibacterium acnes inhibit survival of melanocytes by increasing apoptosis[J]. Photodermatol Photoimmunol Photomed, 2018,34(6):405⁃414. doi: 10.1111/phpp.12411. |
| [42] | Li H, Goh BN, Teh WK, et al. Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation[J]. J Invest Dermatol, 2018,138(5):1137⁃1145. doi: 10.1016/j.jid.2017.11.034. |
| [43] | Wood DLA,Lachner N,Tan J⁃M,et al. A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes[J]. mBio, 2018,9(5):e01432⁃18. doi: 10.1128/mBio.01432⁃18. |
| [44] | Sato Y, Fujimura T, Tanita K, et al. Malassezia⁃derived aryl hydrocarbon receptor ligands enhance the CCL20/Th17/soluble CD163 pathogenic axis in extra⁃mammary Paget′s disease[J]. Exp Dermatol, 2019,28(8):933⁃939. doi: 10.1111/exd.13944. |
| [45] | Friedrich AD, Campo VE, Cela EM, et al. Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB⁃induced immunosuppression and impairs skin tumor growth in mice[J]. Eur J Immunol, 2019,49(11):2095⁃2102. doi: 10.1002/eji.201848024. |
| [46] | Kianmehr S, Jahani M, Moazzen N, et al. The potential of probiotics for treating skin disorders: a concise review[J]. Curr Pharm Biotechnol, 2022,23(15):1851⁃1863. doi: 10.2174/138920 1023666220411090301. |
| [47] | Lizardo M,Magalhães RM,Tavaria FK. Probiotic adhesion to skin keratinocytes and underlying mechanisms [J]. Biology (Basel), 2022,11(9):1372. doi:10.3390/biology11091372. |
| [48] | Petrov A, Ćorović M, Milivojević A, et al. Prebiotic effect of galacto⁃oligosaccharides on the skin microbiota and determination of their diffusion properties[J]. Int J Cosmet Sci, 2022,44(3):309⁃319. doi: 10.1111/ics.12778. |
| [49] | Le Bourgot C, Meunier C, Gaio E, et al. Effects of short chain fructo⁃oligosaccharides on selected skin bacteria[J]. Sci Rep, 2022,12(1):9702. doi: 10.1038/s41598⁃022⁃13093⁃5. |
| [1] | 薛天萍 陆振中 王洪生. [开放获取] 银屑病发病机制与微生物菌群相关性研究进展[J]. 中华皮肤科杂志, 2026, 59(1): 89-92. |
| [2] | 周妙妮 盛安琪 傅丽芳 金嵘 许文 尉晓冬 许爱娥. 茶多酚抗氧化凝胶联合窄谱中波紫外线治疗白癜风的疗效及安全性单中心随机对照试验[J]. 中华皮肤科杂志, 2025, 58(9): 834-838. |
| [3] | 张成锋 金尚霖. 黄褐斑发病机制与临床对策的新认识[J]. 中华皮肤科杂志, 2025, 58(9): 797-800. |
| [4] | 谭薇 白云 陈裕充 徐明圆 刘业强. 国内首报CRTC1::TRIM11融合皮肤肿瘤1例[J]. 中华皮肤科杂志, 2025, 58(9): 825-828. |
| [5] | 洪永镇 王倩 梁俊琴. 二代测序技术在非遗传性皮肤病领域中的运用[J]. 中华皮肤科杂志, 2025, 58(8): 793-796. |
| [6] | 李家明 王鹏 康晓静. 皮肤恶性肿瘤铁死亡机制与相关干预措施研究进展[J]. 中华皮肤科杂志, 2025, 0(3): 20240125-e20240125. |
| [7] | 李安琪 孙秋宁. 脑源性神经营养因子与皮肤病[J]. 中华皮肤科杂志, 2025, 58(2): 190-193. |
| [8] | 中华医学会皮肤性病学分会免疫学组. 肠道菌群移植治疗免疫介导性皮肤病指南(2025版)[J]. 中华皮肤科杂志, 2025, 58(12): 1112-1120. |
| [9] | 李丽 张斌 徐教生 孙娟 陈云刘 马琳. 生长与治愈的平衡:儿童皮肤肿瘤与脉管畸形治疗的特殊性考量[J]. 中华皮肤科杂志, 2025, 58(10): 914-923. |
| [10] | 郑娜娜 曾荣 陶盈凯 李岷. 环状RNA与皮肤肿瘤相关性研究进展[J]. 中华皮肤科杂志, 2025, 58(10): 999-1002. |
| [11] | 王奇飒 赵文玲 韩秀峰 马焕跃 石海涛 马琳 徐哲. 婴幼儿舒缓特护霜改善婴儿期特应性皮炎复发的功效性研究:一项随机对照试验[J]. 中华皮肤科杂志, 2025, 58(10): 975-979. |
| [12] | 中国中西医结合学会皮肤性病专业委员会 中华医学会皮肤性病学分会 中国医师协会皮肤科医师分会. 常见非黑素细胞性皮肤肿瘤的反射式共聚焦显微镜特征专家共识(2025版)[J]. 中华皮肤科杂志, 2025, 58(1): 20-33. |
| [13] | 艾芳婷 孙紫君 苗国英 姚春霞. 钙敏感受体在老年皮肤病理生理中的作用研究进展[J]. 中华皮肤科杂志, 2025, 58(1): 76-79. |
| [14] | 张嘉琪 吴凡 韩雨晴 刘琦 盘瑶. 多光子显微镜在皮肤科中的应用[J]. 中华皮肤科杂志, 2024, 57(9): 857-862. |
| [15] | 中国中西医结合学会皮肤性病专业委员会 中华医学会皮肤性病学分会 中国医师协会皮肤科医师分会. 反射式共聚焦显微镜在常见黑素细胞性皮肤肿瘤中的应用专家共识(2024版)[J]. 中华皮肤科杂志, 2024, 57(9): 775-784. |
|