环状RNA与皮肤肿瘤相关性研究进展

doi:10.35541/cjd.20210893

中华皮肤科杂志 ›› 2023, e20210893.doi: 10.35541/cjd.20210893

环状RNA与皮肤肿瘤相关性研究进展

郑娜娜¹ 曾荣^2，3 陶盈凯⁴ 李岷^1，3

¹中国医学科学院、北京协和医学院皮肤病医院真菌科，南京 210042；²中国医学科学院、北京协和医学院皮肤病医院激光科，南京 210042；³江苏省皮肤性病分子生物学重点实验室，南京 210042；⁴常州市第一人民医院皮肤科，常州 213000

收稿日期:2021-12-10 修回日期:2022-04-26 发布日期:2023-03-20
通讯作者: 李岷
基金资助:
常州市应用基础研究项目（CJ20210145）

Relationship between circular RNAs and skin tumors

Zheng Nana¹, Zeng Rong^2,3, Tao Yingkai⁴, Li Min^1,3

¹Department of Mycology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; ²Department of Laser, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; ³Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China; ⁴Department of Dermatology, The First People′s Hospital of Changzhou, Changzhou 213000, Jiangsu, China

Received:2021-12-10 Revised:2022-04-26 Published:2023-03-20
Supported by:
Changzhou Application Foundation Project（CJ20210145）

摘要/Abstract

摘要： 【摘要】环状RNA是一种具有共价闭环结构的内源性非编码RNA，与其他非编码RNA相比，环状RNA具有结构稳定、丰度高和组织表达特异的特点。最近研究表明，环状RNA可以作为microRNA和蛋白质的海绵、诱饵及反应支架，在皮肤肿瘤中发挥作用。本文总结了近年环状RNA在常见皮肤肿瘤中的功能和作用机制的研究进展，以了解其影响皮肤肿瘤的方式，评估其进一步的研究价值。

关键词: 皮肤肿瘤, 痣和黑素瘤, 肿瘤, 鳞状细胞, 肿瘤, 基底细胞, 血管肉瘤, 环状RNA

Abstract: 【Abstract】 Circular RNAs （circRNAs） are a type of endogenous noncoding RNAs with covalently looped structures. Compared with other noncoding RNAs, circRNAs have the characteristics of stable structures, high abundance and tissue-specific expression. Recent studies have demonstrated that circRNAs can act as sponges, decoys and scaffolds for microRNAs and proteins, and play an important role in skin tumors. This review summarizes recent advances in the functions and mechanisms of action of circRNAs in common skin tumors, in order to understand the way in which they affect skin tumors, and to assess the value of further research on them.

Key words: Skin neoplasms, Nevi and melanoma, Neoplasms, squamous cell, Neoplasms, basal cell, Hemangiosarcoma, circRNA

郑娜娜曾荣, 陶盈凯李岷, . 环状RNA与皮肤肿瘤相关性研究进展[J]. 中华皮肤科杂志, 2023,e20210893. doi:10.35541/cjd.20210893

Zheng Nana, Zeng Rong, Tao Yingkai, Li Min, . Relationship between circular RNAs and skin tumors[J]. Chinese Journal of Dermatology,2023,e20210893. doi:10.35541/cjd.20210893

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环状RNA与皮肤肿瘤相关性研究进展

Relationship between circular RNAs and skin tumors

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