中华皮肤科杂志 ›› 2022, e20220135.doi: 10.35541/cjd.20220135

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铁死亡在黑素瘤中的研究进展

张聪聪    陈浩   

  1. 中国医学科学院、北京协和医学院皮肤病研究所病理科,南京  210042
  • 收稿日期:2022-03-02 修回日期:2022-08-03 发布日期:2022-11-11
  • 通讯作者: 陈浩 E-mail:ch76ch@163.com
  • 基金资助:
    江苏省自然科学基金(BK20211026);江苏省卫生健康委医学科研项目(M2021045);南京市国家级临床医学中心培育计划项目(2019060001)

Ferroptosis in melanoma

Zhang Congcong, Chen Hao   

  1. Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2022-03-02 Revised:2022-08-03 Published:2022-11-11
  • Contact: Chen Hao E-mail:ch76ch@163.com
  • Supported by:
    Natural Science Foundation of Jiangsu Province (BK20211026); Medical Research Project of Jiangsu Provincial Health Commission (M2021045); The Nanjing Incubation Program for National Clinical Research Center (2019060001)

摘要: 【摘要】 铁死亡是一种新发现的铁依赖调控细胞死亡的形式,与多种癌症包括黑素瘤发展有关。本文综述了近年铁死亡在黑素瘤发病、转移及治疗中的研究进展,旨在为临床开发新型药物及制定黑素瘤治疗新策略提供一定理论基础。

关键词: 痣和黑素瘤, 细胞死亡, 脂质过氧化作用, 铁死亡

Abstract: 【Abstract】 Ferroptosis, a newly discovered form of iron-dependent regulation of cell death, has been found to be associated with the development of various cancers, including melanoma. This review summarizes recent progress in roles of ferroptosis in the pathogenesis, metastasis and treatment of melanoma, aiming to provide a theoretical basis for the development of new drugs and new treatment strategies for melanoma in clinical practice.

Key words: Nevi and melanoma, Cell death, Lipid peroxidation, Ferroptosis

中图分类号: 

  • R751

引用本文

张聪聪 陈浩. 铁死亡在黑素瘤中的研究进展[J]. 中华皮肤科杂志, 2022,e20220135. doi:10.35541/cjd.20220135

Zhang Congcong, Chen Hao. Ferroptosis in melanoma[J]. Chinese Journal of Dermatology,2022,e20220135. doi:10.35541/cjd.20220135