程序性细胞死亡蛋白1/程序性细胞死亡蛋白配体1抑制剂相关的Stevens-Johnson综合征/中毒性表皮坏死松解症研究进展

doi:10.35541/cjd.20220644

中华皮肤科杂志 ›› 2024, e20220644.doi: 10.35541/cjd.20220644

程序性细胞死亡蛋白1/程序性细胞死亡蛋白配体1抑制剂相关的Stevens-Johnson综合征/中毒性表皮坏死松解症研究进展

姚曼雪周乃慧

苏州大学附属第一医院皮肤科，苏州 215006

收稿日期:2022-09-07 修回日期:2023-06-20 发布日期:2024-05-08
通讯作者: 周乃慧 E-mail:zhounaihui@163.com
基金资助:
国家自然科学基金（81703144）

Stevens-Johnson syndrome/toxic epidermal necrolysis associated with programmed death-1/programmed death-ligand 1 inhibitors

Yao Manxue, Zhou Naihui

Department of Dermatology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China

Received:2022-09-07 Revised:2023-06-20 Published:2024-05-08
Contact: Zhou Naihui E-mail:zhounaihui@163.com
Supported by:
National Natural Science Foundation of China（81703144）

摘要/Abstract

摘要： 【摘要】以程序性细胞死亡蛋白1（PD-1）/程序性细胞死亡蛋白配体1（PD-L1）抑制剂为代表的免疫检查点抑制剂是治疗恶性肿瘤的突破方案，随之而来的免疫治疗相关不良反应不容忽视，而Stevens-Johnson综合征（SJS）/中毒性表皮坏死松解症（TEN）则是其最为严重的表现之一，可危及生命。与其他药物引起的SJS/TEN相比，PD-1/PD-L1抑制剂相关的SJS/TEN潜伏期往往更长，皮损更为泛发和严重，易发生严重感染和器官衰竭等并发症，预后差，死亡率更高，故早期发现并正确处理有重要的意义。本文综述目前PD-1/PD-L1抑制剂相关的SJS/TEN研究进展。

关键词: 程序性细胞死亡受体1, 抗原, CD274, Stevens-Johnson综合征, 药物毒性, 自身免疫, 生物制剂

Abstract: 【Abstract】 Immune checkpoint inhibitors, represented by programmed death-1 （PD-1）/programmed death-ligand 1 （PD-L1） inhibitors, are a breakthrough in the treatment of malignant tumors, and the following immune-related adverse events cannot be ignored. Stevens-Johnson syndrome （SJS）/toxic epidermal necrolysis （TEN） is one of the most serious adverse events, which can be life-threatening. Compared with SJS/TEN caused by other drugs, SJS/TEN associated with PD-1/PD-L1 inhibitors tends to have a longer latent period, more extensive and more severe skin lesions, higher risk of complications such as severe infection and organ failure, poorer prognosis, and higher mortality. So, early diagnosis and correct treatment are of great significance. This review summarizes current research progress in SJS/TEN associated with PD-1/PD-L1 inhibitors.

Key words: Programmed cell death 1 receptor, Antigens, CD274, Stevens-Johnson syndrome, Drug toxicity, Autoimmunity, Biological agents

姚曼雪周乃慧. 程序性细胞死亡蛋白1/程序性细胞死亡蛋白配体1抑制剂相关的Stevens-Johnson综合征/中毒性表皮坏死松解症研究进展 [J]. 中华皮肤科杂志, 2024,e20220644. doi:10.35541/cjd.20220644

Yao Manxue, Zhou Naihui. Stevens-Johnson syndrome/toxic epidermal necrolysis associated with programmed death-1/programmed death-ligand 1 inhibitors[J]. Chinese Journal of Dermatology,2024,e20220644. doi:10.35541/cjd.20220644

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程序性细胞死亡蛋白1/程序性细胞死亡蛋白配体1抑制剂相关的Stevens-Johnson综合征/中毒性表皮坏死松解症研究进展

Stevens-Johnson syndrome/toxic epidermal necrolysis associated with programmed death-1/programmed death-ligand 1 inhibitors

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