皮肤微生物与皮肤肿瘤相关性的研究进展

doi:10.35541/cjd.20230241

中华皮肤科杂志 ›› 2024, e20230241.doi: 10.35541/cjd.20230241

皮肤微生物与皮肤肿瘤相关性的研究进展

刘莹莹,邓丹琪

昆明医科大学第二附属医院皮肤科，昆明 650101

收稿日期:2023-04-27 修回日期:2024-01-13 发布日期:2024-05-17
通讯作者: 邓丹琪 E-mail:danqid128@sina.com

Correlations between skin microbiome and skin tumors

Liu Yingying, Deng Danqi

Department of Dermatology and Venereology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China

Received:2023-04-27 Revised:2024-01-13 Published:2024-05-17
Contact: Deng Danqi E-mail:danqid128@sina.com

摘要/Abstract

摘要： 【摘要】近年来，皮肤肿瘤的发病率不断上升且患者日趋年轻化，对人类健康造成很大威胁，但其发病机制和病因仍未完全明确。多项研究表明，皮肤微生物组与皮肤肿瘤的发生、发展密切相关。本文就皮肤肿瘤的皮肤微生态失调，对皮肤屏障和免疫系统的影响及微生态治疗进行综述，以期为皮肤肿瘤的早期诊断及治疗提供新思路。

关键词: 皮肤肿瘤, 微生物群落, 生物群, 葡萄球菌皮肤感染, 金黄色葡萄球菌, 免疫系统, 益生元, 皮肤屏障

Abstract: 【Abstract】 In recent years, the incidence of skin tumors has been increasing, and patients are becoming younger, posing a great threat to human health. However, their pathogenesis and etiology are not yet fully elucidated. Multiple studies have shown that skin microbiome is closely related to the occurrence and development of skin tumors. This review summarizes microecological disorders in skin tumors, their effects on the skin barrier and skin immune system,

Key words: Skin neoplasms, Microbial consortia, Biota, Staphylococcal skin infections, Staphylococcus aureus, Immune system, Prebiotics, Skin barrier

刘莹莹邓丹琪. 皮肤微生物与皮肤肿瘤相关性的研究进展[J]. 中华皮肤科杂志, 2024,e20230241. doi:10.35541/cjd.20230241

Liu Yingying, Deng Danqi. Correlations between skin microbiome and skin tumors[J]. Chinese Journal of Dermatology,2024,e20230241. doi:10.35541/cjd.20230241

参考文献 49

［1］	Richardson BN, Lin J, Buchwald ZS, et al. Skin microbiome and treatment⁃related skin toxicities in patients with cancer: a mini⁃review［J］. Front Oncol, 2022,12:924849. doi: 10.3389/fonc. 2022.924849.
［2］	Kapoor B, Gulati M, Rani P, et al. Psoriasis: interplay between dysbiosis and host immune system［J］. Autoimmun Rev, 2022,21（11）:103169. doi: 10.1016/j.autrev.2022.103169.
［3］	Schneider AM, Nolan ZT, Banerjee K, et al. Evolution of the facial skin microbiome during puberty in normal and acne skin［J］. J Eur Acad Dermatol Venereol, 2023,37（1）:166⁃175. doi: 10.1111/jdv.18616.
［4］	Gao YW, Yao X, Yang XY. Application of bioengineered bacteria in allergic diseases［J］. Int J Dermatol Venerol, 2023,6（1）:43⁃48. doi: 10.1097/JD9.0000000000000242.
［5］	Łyko M, Jankowska⁃Konsur A. The skin microbiome in cutaneous T⁃cell lymphomas （CTCL）⁃a narrative review［J］. Pathogens, 2022,11（8）:935. doi: 10.3390/pathogens11080935.
［6］	Jost M, Wehkamp U. The skin microbiome and influencing elements in cutaneous T⁃cell lymphomas［J］. Cancers （Basel）, 2022,14（5）:1324. doi: 10.3390/cancers14051324.
［7］	郑娜娜, 曾荣, 陶盈凯, 等. 环状RNA与皮肤肿瘤相关性研究进展［J］. 中华皮肤科杂志, 2023,e20210893. doi: 10.35541/cjd.20210893.
［8］	Squarzanti DF, Zavattaro E, Pizzimenti S, et al. Non⁃melanoma skin cancer: news from microbiota research［J］. Crit Rev Microbiol, 2020,46（4）:433⁃449. doi: 10.1080/1040841X.2020. 1794792.
［9］	Parida S, Sharma D. The microbiome and cancer: creating friendly neighborhoods and removing the foes within［J］. Cancer Res, 2021,81（4）:790⁃800. doi: 10.1158/0008⁃5472.CAN⁃20⁃2629.
［10］	Kennedy MS, Chang EB. The microbiome: composition and locations［J］. Prog Mol Biol Transl Sci, 2020,176:1⁃42. doi: 10. 1016/bs.pmbts.2020.08.013.
［11］	Luna PC. Skin microbiome as years go by［J］. Am J Clin Dermatol, 2020,21（Suppl 1）:12⁃17. doi: 10.1007/s40257⁃020⁃00549⁃5.
［12］	Byrd AL, Belkaid Y, Segre JA. The human skin microbiome［J］. Nat Rev Microbiol, 2018,16（3）:143⁃155. doi: 10.1038/nrmicro. 2017.157.
［13］	闫慧敏, 姜薇. 人类皮肤微生物群和皮肤疾病［J］. 中国皮肤性病学杂志, 2015,29（12）:1292⁃1294. doi: 10.13735/j.cjdv. 1001⁃7089.201412052.
［14］	Wood D, Lachner N, Tan JM, et al. A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes［J］. mBio, 2018,9（5）:e01432⁃18. doi: 10.1128/mBio.01432⁃18.
［15］	Blümel E, Munir Ahmad S, Nastasi C, et al. Staphylococcus aureus alpha⁃toxin inhibits CD8+ T cell⁃mediated killing of cancer cells in cutaneous T⁃cell lymphoma［J］. Oncoimmunology, 2020,9（1）:1751561. doi: 10.1080/2162402X.2020.1751561.
［16］	Nakatsuji T, Chen TH, Butcher AM, et al. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia［J］. Sci Adv, 2018,4（2）:eaao4502. doi: 10.1126/sciadv.aao4502.
［17］	Mizuhashi S, Kajihara I, Sawamura S, et al. Skin microbiome in acral melanoma: Corynebacterium is associated with advanced melanoma［J］. J Dermatol, 2021,48（1）:e15⁃e16. doi: 10.1111/1346⁃8138.15633.
［18］	Mrázek J, Mekadim C, Kučerová P, et al. Melanoma⁃related changes in skin microbiome［J］. Folia Microbiol （Praha）, 2019,64（3）:435⁃442. doi: 10.1007/s12223⁃018⁃00670⁃3.
［19］	Kumar P, Brazel D, DeRogatis J, et al. The cure from within? A review of the microbiome and diet in melanoma［J］. Cancer Metastasis Rev, 2022,41（2）:261⁃280. doi: 10.1007/s10555⁃022⁃10029⁃3.
［20］	Gluud M, Pallesen E, Buus TB, et al. Malignant T cells induce skin barrier defects through cytokine⁃mediated JAK/STAT signaling in cutaneous T⁃cell lymphoma［J］. Blood, 2023,141（2）:180⁃193. doi: 10.1182/blood.2022016690.
［21］	Edslev SM, Agner T, Andersen PS. Skin microbiome in atopic dermatitis［J］. Acta Derm Venereol, 2020,100（12）:adv00164. doi: 10.2340/00015555⁃3514.
［22］	Bosman ES, Albert AY, Lui H, et al. Skin exposure to narrow band ultraviolet （UVB） light modulates the human intestinal microbiome［J］. Front Microbiol, 2019,10:2410. doi: 10.3389/fmicb.2019.02410.
［23］	Wang X，Koffi PF，English OF，et al. Staphylococcus aureus extracellular vesicles: a story of toxicity and the stress of 2020 ［J］. Toxins （Basel）, 2021,13（2）:75. doi: 10.3390/toxins13020075.
［24］	Krueger A，Mohamed A，Kolka CM，et al. Skin cancer⁃associated S. aureus strains can induce DNA damage in human keratinocytes by downregulating DNA repair and promoting oxidative stress［J］. Cancers （Basel）, 2022,14（9）:2143. doi:10.3390/cancers14092143.
［25］	Quintero⁃Fabián S, Arreola R, Becerril⁃Villanueva E, et al. Role of matrix metalloproteinases in angiogenesis and cancer［J］. Front Oncol, 2019,9:1370. doi: 10.3389/fonc.2019.01370.
［26］	Nauroy P, Nyström A. Kallikreins: Essential epidermal messengers for regulation of the skin microenvironment during homeostasis, repair and disease［J］. Matrix Biol Plus, 2020,6⁃7:100019. doi: 10.1016/j.mbplus.2019.100019.
［27］	Krueger A, Zaugg J, Chisholm S, et al. Secreted toxins from Staphylococcus aureus strains isolated from keratinocyte skin cancers mediate pro⁃tumorigenic inflammatory responses in the skin［J］. Front Microbiol, 2021,12:789042. doi: 10.3389/fmicb. 2021.789042.
［28］	Duan T，Du Y，Xing C，et al. Toll⁃like receptor signaling and its role in cell⁃mediated immunity［J］. Front Immunol, 2022,13:812774. doi:10.3389/fimmu.2022.812774.
［29］	Blohm⁃Mangone K, Burkett NB, Tahsin S, et al. Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV⁃induced skin tumorigenesis in SKH⁃1 mice［J］. Cancer Prev Res （Phila）, 2018,11（5）:265⁃278. doi: 10.1158/1940⁃6207.CAPR⁃17⁃0349.
［30］	Mann JE, Ludwig ML, Kulkarni A, et al. Microbe⁃mediated activation of Toll⁃like receptor 2 drives PDL1 expression in HNSCC［J］. Cancers （Basel）, 2021,13（19）:4782. doi: 10.3390/cancers13194782.
［31］	Kiatsurayanon C, Ogawa H, Niyonsaba F. The role of host defense peptide human β⁃defensins in the maintenance of skin barriers［J］. Curr Pharm Des, 2018,24（10）:1092⁃1099. doi: 10. 2174/1381612824666180327164445.
［32］	Madhusudhan N，Pausan MR，Halwachs B，et al. Molecular profiling of keratinocyte skin tumors links Staphylococcus aureus overabundance and increased human β⁃defensin⁃2 expression to growth promotion of squamous cell carcinoma ［J］. Cancers （Basel）, 2020,12（3）:541. doi: 10.3390/cancers12030541.
［33］	Nakagawa S, Matsumoto M, Katayama Y, et al. Staphylococcus aureus virulent PSMα peptides induce keratinocyte alarmin release to orchestrate IL⁃17⁃dependent skin inflammation［J］. Cell Host Microbe, 2017,22（5）:667⁃677.e5. doi: 10.1016/j.chom. 2017.10.008.
［34］	Ridaura VK, Bouladoux N, Claesen J, et al. Contextual control of skin immunity and inflammation by Corynebacterium［J］. J Exp Med, 2018,215（3）:785⁃799. doi: 10.1084/jem.20171079.
［35］	Sakamoto R, Kajihara I, Mijiddorj T, et al. Existence of Staphylococcus aureus correlates with the progression of extramammary Paget′s disease: potential involvement of interleukin⁃17 and M2⁃like macrophage polarization［J］. Eur J Dermatol, 2021,31（1）:48⁃54. doi: 10.1684/ejd.2021.3972.
［36］	Willerslev⁃Olsen A, Krejsgaard T, Lindahl LM, et al. Staphylococcal enterotoxin A （SEA） stimulates STAT3 activation and IL⁃17 expression in cutaneous T⁃cell lymphoma［J］. Blood, 2016,127（10）:1287⁃1296. doi: 10.1182/blood⁃2015⁃08⁃662353.
［37］	Willerslev⁃Olsen A, Gjerdrum L, Lindahl LM, et al. Staphylococcus aureus induces signal transducer and activator of transcription 5⁃dependent miR⁃155 expression in cutaneous T⁃cell lymphoma［J］. J Invest Dermatol, 2021,141（10）:2449⁃2458. doi: 10.1016/j.jid.2021.01.038.
［38］	Lindahl LM, Willerslev⁃Olsen A, Gjerdrum L, et al. Antibiotics inhibit tumor and disease activity in cutaneous T⁃cell lymphoma［J］. Blood, 2019,134（13）:1072⁃1083. doi: 10.1182/blood.2018 888107.
［39］	Blümel E, Willerslev⁃Olsen A, Gluud M, et al. Staphylococcal alpha⁃toxin tilts the balance between malignant and non⁃malignant CD4+ T cells in cutaneous T⁃cell lymphoma［J］. Oncoimmunology, 2019,8（11）:e1641387. doi: 10.1080/2162402X. 2019.1641387.
［40］	Glatthardt T，Campos JC de M，Chamon RC，et al. Small molecules produced by commensal Staphylococcus epidermidis disrupt formation of biofilms by staphylococcus aureus ［J］. Appl Environ Microbiol, 2020,86（5）:e02539⁃19. doi:10.1128/AEM. 02539⁃19.
［41］	Wang Z, Choi JE, Wu CC, et al. Skin commensal bacteria Staphylococcus epidermidis promote survival of melanocytes bearing UVB⁃induced DNA damage, while bacteria Propionibacterium acnes inhibit survival of melanocytes by increasing apoptosis［J］. Photodermatol Photoimmunol Photomed, 2018,34（6）:405⁃414. doi: 10.1111/phpp.12411.
［42］	Li H, Goh BN, Teh WK, et al. Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation［J］. J Invest Dermatol, 2018,138（5）:1137⁃1145. doi: 10.1016/j.jid.2017.11.034.
［43］	Wood DLA，Lachner N，Tan J⁃M，et al. A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes［J］. mBio, 2018,9（5）:e01432⁃18. doi: 10.1128/mBio.01432⁃18.
［44］	Sato Y, Fujimura T, Tanita K, et al. Malassezia⁃derived aryl hydrocarbon receptor ligands enhance the CCL20/Th17/soluble CD163 pathogenic axis in extra⁃mammary Paget′s disease［J］. Exp Dermatol, 2019,28（8）:933⁃939. doi: 10.1111/exd.13944.
［45］	Friedrich AD, Campo VE, Cela EM, et al. Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB⁃induced immunosuppression and impairs skin tumor growth in mice［J］. Eur J Immunol, 2019,49（11）:2095⁃2102. doi: 10.1002/eji.201848024.
［46］	Kianmehr S, Jahani M, Moazzen N, et al. The potential of probiotics for treating skin disorders: a concise review［J］. Curr Pharm Biotechnol, 2022,23（15）:1851⁃1863. doi: 10.2174/138920 1023666220411090301.
［47］	Lizardo M，Magalhães RM，Tavaria FK. Probiotic adhesion to skin keratinocytes and underlying mechanisms ［J］. Biology （Basel）, 2022,11（9）:1372. doi:10.3390/biology11091372.
［48］	Petrov A, Ćorović M, Milivojević A, et al. Prebiotic effect of galacto⁃oligosaccharides on the skin microbiota and determination of their diffusion properties［J］. Int J Cosmet Sci, 2022,44（3）:309⁃319. doi: 10.1111/ics.12778.
［49］	Le Bourgot C, Meunier C, Gaio E, et al. Effects of short chain fructo⁃oligosaccharides on selected skin bacteria［J］. Sci Rep, 2022,12（1）:9702. doi: 10.1038/s41598⁃022⁃13093⁃5.

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皮肤微生物与皮肤肿瘤相关性的研究进展

Correlations between skin microbiome and skin tumors

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