缺氧诱导因子1α在自身免疫性皮肤病中的研究进展

doi:10.35541/cjd.20250202

中华皮肤科杂志 ›› 2026, e20250202.doi: 10.35541/cjd.20250202

缺氧诱导因子1α在自身免疫性皮肤病中的研究进展

陈若琳曹妍

南京医科大学第三附属医院（常州市第二人民医院）皮肤科南京医科大学常州医学中心，常州 213000

收稿日期:2025-04-11 修回日期:2026-02-02 发布日期:2026-05-27
通讯作者: 曹妍 E-mail:czeycy2018@163.com
基金资助:
常州市卫健委重大项目（ZD202439）；南京医科大学常州医学中心临床研究项目（CMCC202408）；南京医科大学教育研究课题（2023LX098）

Hypoxia-inducible factor-1α in autoimmune skin diseases

Chen Ruolin, Cao Yan

Department of Dermatology, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, China

Received:2025-04-11 Revised:2026-02-02 Published:2026-05-27
Contact: Cao Yan E-mail:czeycy2018@163.com
Supported by:
Major Science and Technology Project of Changzhou Health Commission（ZD202439）; Changzhou Medical Center of Nanjing Medical University Program （CMCC202408）; Educational Research Project of Nanjing Medical University （2023LX098）

摘要/Abstract

摘要： 【摘要】缺氧诱导因子1α作为一种高度保守的转录因子，在响应氧水平变化、细胞代谢、调节细胞因子及细胞免疫功能中发挥重要作用。越来越多研究表明，缺氧诱导因子1α在银屑病、特应性皮炎、系统性红斑狼疮、斑秃、白癜风、系统性硬化症等自身免疫性皮肤病中发挥重要作用。本文综述缺氧诱导因子1α在自身免疫性皮肤病中的研究进展，展望其在皮肤科领域的研究与应用。

关键词: 缺氧诱导因子1, α亚基, 银屑病, 皮炎, 特应性, 红斑狼疮, 系统性, 斑秃, 白癜风, 硬皮病, 系统性, 身免疫性皮肤病

Abstract: 【Abstract】 Hypoxia-inducible factor 1α (HIF-1α), a highly conserved transcription factor, plays an important role in responding to changes in oxygen levels, cellular metabolism, and the regulation of cytokines and immune cell functions. Increasing evidence has demonstrated that HIF-1α plays a critical role in autoimmune skin diseases, including psoriasis, atopic dermatitis, systemic lupus erythematosus, alopecia areata, vitiligo, and systemic sclerosis. This article reviews the research progress on HIF-1α in autoimmune skin diseases and discusses its future research prospects and potential applications in dermatology.

Key words: Hypoxia-inducible factor 1, alpha Subunit, Autoimmune dermatosis, Psoriasis, Dermatitis, atopic, Lupus erythematosus, systemic, Alopecia areata, Vitiligo, Scleroderma, systemic

陈若琳曹妍. 缺氧诱导因子1α在自身免疫性皮肤病中的研究进展[J]. 中华皮肤科杂志, 2026,e20250202. doi:10.35541/cjd.20250202

Chen Ruolin, Cao Yan. Hypoxia-inducible factor-1α in autoimmune skin diseases[J]. Chinese Journal of Dermatology,2026,e20250202. doi:10.35541/cjd.20250202

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缺氧诱导因子1α在自身免疫性皮肤病中的研究进展

Hypoxia-inducible factor-1α in autoimmune skin diseases

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