Chinese Journal of Dermatology ›› 2024, e20230405.doi: 10.35541/cjd.20230405

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Synthesis and related immunological effects of sebum lipids

Cheng Shuqiong, Zhong Meizhen, Zheng Siqi, Zeng Kang, Huang Xiaowen   

  1. Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:2023-07-17 Revised:2024-05-03 Online:2024-01-29 Published:2024-09-29
  • Contact: Huang Xiaowen E-mail:huangxw@smu.edu.cn
  • Supported by:
    Guangzhou Science and Technology Planning Project(202201011376)

Abstract: 【Abstract】 Sebaceous gland lipids are the main components of sebum, and their synthesis is affected by a variety of factors. Sebaceous gland lipids possess multiple immunological effects, playing a crucial role in skin immunity, and changes in their content and composition can affect the occurrence and development of inflammatory skin diseases. This review summarizes the main factors affecting the synthesis of sebaceous gland lipids and their immunological effects, aiming to provide insights for the clinical treatment of inflammatory skin diseases.

Key words: Sebaceous glands, Lipids, Immunomodulation, Sterol regulatory element binding protein 1, Peroxisome proliferator-activated receptors, Neuropeptides, Endocannabinoids, Inflammatory dermatosis