脂质组学在痤疮皮脂分析中的应用

doi:10.35541/cjd.20190535

Abstract

Abstract: Acne is a chronic inflammatory dermatosis of pilosebaceous units. Increased sebum content is the precondition of acne occurrence, and changes of sebum components promote inflammatory reactions in acne. Imbalance of sebum homeostasis is one of the key factors for acne occurrence. Due to the complex composition and diverse structure of sebum, it is difficult to analyze all lipid compounds in sebum by using a single experimental method. Lipidomics can be used to qualitatively and quantitatively analyze hundreds of lipids with different properties and biological activities, which provides a potential insight into the role of sebum in the pathogenesis of acne. This review summarizes application of lipidomics in the analysis of sebum in acne patients.

Key words: Acne vulgaris, Fatty acids, nonesterified, Squalene, Ceramides, Peroxisome proliferator-activated receptors, Lipidomics, Sebum homeostasis imbalance

Wei Lu, Zhu Mingfang, Ju Qiang. Application of lipidomics in the analysis of sebum in acne patients[J]. Chinese Journal of Dermatology, 2020, 53(10): 853-856.doi:10.35541/cjd.20190535

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Application of lipidomics in the analysis of sebum in acne patients

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