Abstract: 【Abstract】 Objective To explore the cognitive characteristics, influencing factors, and treatment needs regarding biologic agents among patients with psoriasis. Methods A cross-sectional study was conducted. Patients with psoriasis attending the Department of Dermatology, Xijing Hospital, Air Force Medical University were selected from October to December 2022, and from June to December 2023. A self-designed electronic questionnaire was used for investigation, covering demographic characteristics, psoriasis history （disease types, disease duration, previous treatments, etc.）, biologics knowledge （sources of awareness, core cognitive dimensions）, and treatment needs. Results The valid questionnaire response rate reached 93.2% （439/471）. The ages of enrolled patients were 35.95 ± 12.57 years, and the disease duration was 7.90 ± 3.26 years. Psoriasis vulgaris was the predominant type （363 cases, 82.69%）. The overall awareness rate of biologics slightly increased from 68.62% （105/153） in 2022 to 72.38% （207/286） in 2023 （P > 0.05）. Primary information sources included new media （WeChat/internet） platforms （168 cases, 53.84%） and peer-to-peer sharing （115 cases, 36.86%）, while physician counseling merely accounted for 9.29% （29 cases） （P < 0.001）. Insufficient knowledge of biologics was manifested primarily as poor awareness of comorbidities （47.60%, 209/439） and treatment monitoring protocols （22.32%, 98/439）. Core concerns regarding biologic therapy included safety （73.34%, 322/439）, economic burden （65.14%, 286/439）, and long-term efficacy （63.55%, 279/439）; 60.13% （264/439） of the patients expected rapid improvement of skin symptoms. As for treatment modalities, 90.20% （396/439） of the patients preferred regimens with extended dosing intervals. Conclusions The patients with psoriasis demonstrated an imbalance in their cognitive structure regarding biologic agents. Their treatment needs exhibited multidimensional characteristics, emphasizing not only rapid clearance of skin lesions but also greater importance of treatment safety and cost-effectiveness.

Key words: Psoriasis, Biological agent, Cognitive status, Treatment demands, Patient education