Abstract: 【Abstract】 Objective To investigate disease characteristics of patients with psoriatic arthritis （PsA） based on the PsA cohort in West China Hospital, so as to provide a reference for clinicians in its diagnosis, treatment, and evaluation strategy formulation. Methods A cross-sectional study was carried out, and a descriptive analysis was conducted on clinical data from PsA patients who were treated at the Department of Dermatology, West China Hospital, Sichuan University between April 2, 2020, and January 21, 2025. Demographic characteristics, clinical manifestations, laboratory and imaging findings, and treatment modalities were analyzed. Results A total of 530 PsA patients were included, of whom 332 （62.6%） were males and 198 （37.4%） were females, with ages of 44.1 ± 12.4 years. Skin lesions preceded joint symptoms in 452 patients （85.3%）, with time intervals （M ［Q1, Q3］） of 8.0 （3.0, 15.0） years. Overweight or obesity was observed in 319 patients （60.2%）, and 188 （35.5%） had comorbid fatty liver. Peripheral joint involvement was common （485 cases, 91.5%）, with the proximal interphalangeal joints being most frequently affected by tenderness （172 cases, 35.5%） and swelling （119 cases, 24.5%）; the number of enthesitis cases identified by ultrasonography （116 cases, 23.9%） was significantly higher than that by clinical examination （82 cases, 15.5%）; axial joint involvement was observed in 258 patients （48.7%）, with the sacroiliac joints most commonly affected （201 cases, 77.9%）. Regarding treatment, conventional systemic drugs were predominant in the treatment of psoriasis prior to the diagnosis of PsA; after the diagnosis of PsA, the number of patients receiving targeted therapies increased to 334 （63.0%）, with interleukin-17 inhibitors being the most common （140 cases, 26.4%）, followed by tumor necrosis factor-α inhibitors （106 cases, 20.0%） and Janus kinase inhibitors （39 cases, 7.4%）. Conclusions PsA predominantly affects males over 40 years old and is characterized by preceding skin lesions, delayed diagnosis, and multiple comorbidities. High-frequency ultrasound has advantages in the early detection of peripheral enthesitis. Further attention is needed for managing comorbidities such as fatty liver and obesity-related metabolic conditions.

Key words: Arthritis, psoriatic, Signs and symptoms, Ultrasonography, Cross-sectional studies, Diagnosis, Therapy, Comorbidity