组织常驻记忆T细胞在自身免疫性皮肤病复发中的作用

doi:10.35541/cjd.20240319

Abstract

Abstract: 【Abstract】 Tissue-resident memory T cells （TRMs） permanently reside in the skin without recirculating through the blood or lymphatic system and provide rapid, antigen-specific immune protection upon pathogen re-exposure. Aberrant activation of TRMs has been implicated in the recurrence of autoimmune skin diseases. This review summarizes the mechanisms underlying the generation, homing, and tissue residency of TRMs and further discusses the evidence supporting their role in the recurrence of psoriasis, vitiligo, lupus erythematosus, pemphigus, and alopecia areata.

Key words: T-lymphocyte subsets, Tissue-resident memory T cells, Autoimmune diseases, Psoriasis, Vitiligo, Pemphigus, Lupus erythematosus, Alopecia areata

Tang Dongmei, Yan Yurou, Xu Yinde, Li Xiaolan. The role of tissue-resident memory T cells in the recurrence of autoimmune skin diseases[J]. Chinese Journal of Dermatology,2026,e20240319. doi:10.35541/cjd.20240319

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The role of tissue-resident memory T cells in the recurrence of autoimmune skin diseases

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