中华皮肤科杂志 ›› 2014, Vol. 47 ›› Issue (5): 337-340.

• 论著 • 上一篇    下一篇

黑素细胞移植治疗甲状腺功能异常白癜风的临床观察

李伟1,洪为松2,傅丽芳3,尉晓冬4,许爱娥5   

  1. 1. 浙江中医药大学附属第三人民医院
    2. 杭州市第三人民医院
    3.
    4. 杭州市第三人民医院皮肤科
    5. 安徽医科大学附属杭州市第三人民医院皮肤科
  • 收稿日期:2013-10-08 修回日期:2013-12-31 发布日期:2014-05-01
  • 通讯作者: 许爱娥 E-mail:xuaiehz@msn.com
  • 基金资助:
    浙江省医药卫生重大科技计划

Autologous melanocyte transplantation for the treatment of vitiligo in patients with abnormal thyroid function: a clinical observation

  • Received:2013-10-08 Revised:2013-12-31 Published:2014-05-01

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摘要： 【摘要】 目的 探讨自体培养黑素细胞移植治疗甲状腺功能异常白癜风的临床疗效。 方法 白癜风患者分为2组，甲状腺功能异常组30例和无甲状腺功能异常组30例。负压吸疱获取患者正常表皮片，体外培养黑素细胞，经2 ～ 5代体外培养，受皮区应用超脉冲CO2激光磨削去表皮后进行黑素细胞移植。所有患者均至少跟踪观察6个月。 结果 30例甲状腺功能异常患者中，平均复色47%，7例复色面积超过90％，9例复色面积为50% ~ 89％，53.3％达到 > 50%的复色。无甲状腺功能异常组平均复色75%，13例达到 > 90%的复色，11例有50% ~ 89%的复色，痊愈率与有效率分别为43.3%、80%，均较甲状腺功能异常组疗效明显，两组间差异有统计学意义（均P < 0.05）。移植部位位于面颈部、移植面积 > 20 cm2时，组间有效率差异也有统计学意义（均P < 0.05）。表皮吸疱于腰部皮肤的痊愈率与有效率均为最差。 结论 临床或亚临床的甲状腺异常会对白癜风的自体黑素细胞移植疗效产生负面影响。

关键词: 白癜风, 黑素细胞, 自体移植, 甲状腺

Abstract: Li Wei, Hong Weisong, Fu Lifang, Wei Xiaodong, Xu Aie. Department of Dermatology, Affiliated Third People′s Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou 310009, China Corresponding author: Xu Aie, Email: xuaiehz@msn.com 【Abstract】 Objective To evaluate the therapeutic efficacy of autologous melanocyte transplantation for the treatment of vitiligo in patients with abnormal thyroid function. Methods A total of 60 patients with vitiligo were enrolled in this study, including 30 with abnormal thyroid function and 30 without. Epidermal sheets were obtained by suction blister biopsy from the normal skin of all the patients followed by melanocyte isolation and culture． After 2 － 5 passages of subculture, the melanocytes were transplanted onto vitiliginous lesions, which were abraded previously by ultra-pulsed CO2 laser, in the corresponding patients. All the patients were followed for 6 － 12 months． Results Of the 30 patients with abnormal thyroid function, 7 patients achieved more than 90% repigmentation, 9 patients 50% － 89% repigmentation, 53.3% more than 50% repigmentation, with the average repigmentation rate being 47% within 6 months after the transplantation. Meanwhile, 13 out of the 30 patients without abnormal thyroid function showed more than 90% repigmentation, 11 showed 50% － 89% repigmentation, with the average repigmentation rate being 75%. Both the cure rate and response rate were significantly higher in the patients without abnormal thyroid function than in those with （cure rate, 43.3% vs. 23.3%, P < 0.05; response rate, 80% vs. 53.3%, P < 0.05）. Significant differences were also found in the response rate for lesions on the face or neck and for those sized more than 20 cm2 between the two groups of patients （both P < 0.05）. The lesions transplanted with epidermal melanocytes from the waist exhibited the lowest cure rate and response rate. Conclusion Clinical or subclinical thyroid dysfunction may have a negative impact on the efficacy of autologous melanocyte transplantation in vitiligo.

Key words: Vitiligo, Melanocytes, Autologous transplantation, Thyroid

引用本文

李伟 洪为松 傅丽芳 尉晓冬 许爱娥. 黑素细胞移植治疗甲状腺功能异常白癜风的临床观察[J]. 中华皮肤科杂志, 2014,47(5):337-340. doi: