组织常驻记忆T细胞在自身免疫性皮肤病复发中的作用

doi:10.35541/cjd.20240319

中华皮肤科杂志 ›› 2026, e20240319.doi: 10.35541/cjd.20240319

组织常驻记忆T细胞在自身免疫性皮肤病复发中的作用

唐冬梅¹ 闫雨柔² 许银德² 李晓岚²

¹重庆医科大学附属儿童医院皮肤科儿童少年健康与疾病国家临床医学研究中心儿童发育疾病研究教育部重点实验室儿童感染与免疫罕见病重庆市重点实验室，重庆 400000；²昆明医科大学第二附属医院皮肤与性病科，昆明 650000

收稿日期:2024-06-18 修回日期:2026-06-07 发布日期:2026-09-22
通讯作者: 唐冬梅

The role of tissue-resident memory T cells in the recurrence of autoimmune skin diseases

Tang Dongmei¹, Yan Yurou², Xu Yinde², Li Xiaolan²

¹Department of Dermatology, Children′s Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing 400000, China; ²Department of Dermatology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China

Received:2024-06-18 Revised:2026-06-07 Published:2026-09-22
Contact: 冬梅唐

摘要/Abstract

摘要： 【摘要】组织常驻记忆T细胞长期驻留于皮肤组织，不进入血液和淋巴循环，当病原体再次入侵时发挥快速特异性免疫保护作用。组织常驻记忆T细胞的异常激活与自身免疫性皮肤病复发相关，本文综述组织常驻记忆T细胞的产生、归巢与驻留机制，进而梳理其在银屑病、白癜风、红斑狼疮、天疱疮及斑秃复发中的作用证据。

关键词: T淋巴细胞亚群, 组织常驻记忆T细胞, 自身免疫疾病, 银屑病, 白癜风, 天疱疮, 红斑狼疮, 斑秃

Abstract: 【Abstract】 Tissue-resident memory T cells （TRMs） permanently reside in the skin without recirculating through the blood or lymphatic system and provide rapid, antigen-specific immune protection upon pathogen re-exposure. Aberrant activation of TRMs has been implicated in the recurrence of autoimmune skin diseases. This review summarizes the mechanisms underlying the generation, homing, and tissue residency of TRMs and further discusses the evidence supporting their role in the recurrence of psoriasis, vitiligo, lupus erythematosus, pemphigus, and alopecia areata.

Key words: T-lymphocyte subsets, Tissue-resident memory T cells, Autoimmune diseases, Psoriasis, Vitiligo, Pemphigus, Lupus erythematosus, Alopecia areata

唐冬梅闫雨柔许银德李晓岚. 组织常驻记忆T细胞在自身免疫性皮肤病复发中的作用[J]. 中华皮肤科杂志, 2026,e20240319. doi:10.35541/cjd.20240319

Tang Dongmei, Yan Yurou, Xu Yinde, Li Xiaolan. The role of tissue-resident memory T cells in the recurrence of autoimmune skin diseases[J]. Chinese Journal of Dermatology,2026,e20240319. doi:10.35541/cjd.20240319

参考文献 37

［1］	Osman M, Park SL, Mackay LK. Tissue⁃resident memory T （TRM ） cells: front⁃line workers of the immune system［J］. Eur J Immunol, 2023,53（11）:e2250060. DOI: 10.1002/eji.202250060.
［2］	Li L, Liu P, Chen C, et al. Advancements in the characterization of tissue resident memory T cells in skin disease［J］. Clin Immunol. 2022,245（12）:109183. DOI: 10.1016/j.clim.2022.109183.
［3］	Dong C, Lin L, Du J. Characteristics and sources of tissue⁃resident memory T cells in psoriasis relapse［J］. Curr Res Immunol, 2023,4:100067. DOI: 10.1016/j.crimmu.2023.100067.
［4］	Chen L, Shen Z. Tissue⁃resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders［J］. Cell Mol Immunol, 2020,17（1）:64⁃75. DOI: 10. 1038/s41423⁃019⁃0291⁃4.
［5］	Jan PN, Jana DA, Silvia AV, et al. CCR4 in cutaneous T⁃cell lymphoma: therapeutic targeting of a pathogenic driver［J］. European journal of immunology, 2021,51（7）:1660⁃1671.
［6］	McCully ML, Ladell K, Andrews R, et al. CCR8 expression defines tissue⁃resident memory T cells in human skin［J］. J Immunol, 2018,200（5）:1639⁃1650. DOI: 10.4049/jimmunol. 1701377.
［7］	Tokura Y, Phadungsaksawasdi P, Kurihara K, et al. Pathophysiology of skin resident memory T cells［J］. Front Immunol, 2020,11:618897. DOI: 10.3389/fimmu.2020.618897.
［8］	Zhu HQ, Xu QN. The roles of skin⁃resident memory T cells in dermatoses［J］. Int J Dermatol Venerol, 2019,2（1）:29⁃32. DOI:10.3760/cma.j.issn.2096⁃5540.2019.01.006.
［9］	甘奕传, 张三泉, 张锡宝. Treg、γδT和TRM细胞在斑块状银屑病免疫病理机制中的研究进展［J］. 中国皮肤性病学杂志, 2023,37（11）:1328⁃1333. DOI: 10.13735/j.cjdv.1001⁃7089.2021 12103.
［10］	Frączek A, Owczarczyk⁃Saczonek A, Placek W. The role of Trm cells in the pathogenesis of vitiligo⁃a review of the current state⁃of⁃the⁃art［J］. Int J Mol Sci, 2020,21（10）:3552. DOI: 10.3390/ijms21103552.
［11］	Zitti B, Hoffer E, Zheng W, et al. Human skin⁃resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a［J］. Immunity, 2023,56（6）:1285⁃1302. DOI: 10.1016/j.immuni.2023.05.003.
［12］	Tian D, Lai Y. The relapse of psoriasis: mechanisms and mysteries［J］. JID Innov, 2022,2（3）:100116. DOI: 10.1016/j.xjidi.2022.100116.
［13］	Kasprowicz⁃Furmańczyk M, Czerwińska J, Placek W, et al. Assessment of the tissue resident memory cells in lesional skin of patients with psoriasis and in healthy skin of healthy volunteers［J］. Int J Environ Res Public Health, 2021,18（21）:1251. DOI: 10.3390/ijerph182111251.
［14］	Whitley SK, Li M, Kashem SW, et al. Local IL⁃23 is required for proliferation and retention of skin⁃resident memory TH17 cells［J］. Sci Immunol, 2022,7（77）:eabq3254. DOI: 10.1126/sciimmunol.abq3254.
［15］	Flora A, Frew JW. A case series of early biologic therapy in guttate psoriasis: targeting resident memory T cell activity as a potential novel therapeutic modality［J］. JAAD Case Rep, 2022,24（5）:82⁃87. DOI: 10.1016/j.jdcr.2022.04.019.
［16］	Lu J, Huang D, Yang N, et al. Better efficacy, lower recurrence rate and decreased CD8+TRM with guselkumab treatment for generalized pustular psoriasis: a prospective cohort study from China［J］. Clin Immunol, 2024,259:109899. DOI: 10.1016/j.clim.2024.109899.
［17］	Boniface K, Jacquemin C, Darrigade AS, et al. Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3［J］. J Invest Dermatol, 2018,138（2）:355⁃364. DOI: 10.1016/j.jid.2017.08.038.
［18］	Ng CY, Chan YP, Chiu YC, et al. Targeting the elevated IFN⁃γ in vitiligo patients by human anti⁃ IFN⁃γ monoclonal antibody hampers direct cytotoxicity in melanocyte［J］. J Dermatol Sci, 2023,110（3）:78⁃88. DOI: 10.1016/j.jdermsci.2023.04.006.
［19］	Richmond JM, Strassner JP, Zapata L, et al. Antibody blockade of IL⁃15 signaling has the potential to durably reverse vitiligo［J］. Sci Transl Med, 2018,10（450）:7710. DOI: 10.1126/scitranslmed.aam7710.
［20］	Bhardwaj S, Rani S, Kumaran MS, et al. Expression of Th17⁃ and Treg⁃specific transcription factors in vitiligo patients［J］. Int J Dermatol, 2020,59（4）:474⁃481. DOI: 10.1111/ijd.14766.
［21］	Chen J, Wang X, Cui T, et al. Th1⁃like Treg in vitiligo: an incompetent regulator in immune tolerance［J］. J Autoimmun,2022,131:102859. DOI:10.1016/j.jaut.2022.102859.
［22］	Shah F, Giri PS, Bharti AH, et al. Compromised melanocyte survival due to decreased suppression of CD4+ & CD8+ resident memory T cells by impaired TRM⁃regulatory T cells in generalized vitiligo patients［J］. Exp Dermatol, 2024,33（1）:e14982. DOI: 10.1111/exd.14982.
［23］	Vale E, Garcia LC. Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects［J］. An Bras Dermatol, 2023,98（3）:355⁃372. DOI: 10.1016/j.abd. 2022.09.005.
［24］	Gu HJ, Song S, Roh JY, et al. Expression pattern of tissue⁃resident memory T cells in cutaneous lupus erythematosus［J］. Lupus, 2021,30（9）:1427⁃1437. DOI: 10.1177/09612033211017218.
［25］	Zhao Z, Zhu H, Li Q, et al. Skin CD4+ Trm cells distinguish acute cutaneous lupus erythematosus from localized discoid lupus erythematosus/subacute cutaneous lupus erythematosus and other skin diseases［J］. J Autoimmun, 2022,128:102811. DOI: 10.1016/j.jaut.2022.102811.
［26］	Ryan GE, Harris JE, Richmond JM. Resident memory T cells in autoimmune skin diseases［J］. Front Immunol, 2021,12:652191. DOI: 10.3389/fimmu.2021.652191.
［27］	Zhou M, Guo C, Li X, et al. JAK/STAT signaling controls the fate of CD8+CD103+ tissue⁃resident memory T cell in lupus nephritis［J］. J Autoimmun, 2020,109:102424. DOI: 10.1016/j.jaut.2020. 102424.
［28］	Ishii N. Significance of anti⁃desmocollin autoantibodies in pemphigus［J］. J Dermatol, 2023,50（2）:132⁃139. DOI: 10.1111/1346⁃8138.16660.
［29］	Schmidt E, Kasperkiewicz M, Joly P. Pemphigus［J］. Lancet, 2019,394（10201）:882⁃894. DOI: 10.1016/S0140⁃6736（19）31778⁃7.
［30］	Fang H, Li Q, Wang G. The role of T cells in pemphigus vulgaris and bullous pemphigoid［J］. Autoimmun Rev, 2020,19（11）:102661. DOI: 10.1016/j.autrev.2020.102661.
［31］	Zou Y, Yuan H, Zhou S, et al. The pathogenic role of CD4+ tissue⁃resident memory T cells bearing T follicular helper⁃like phenotype in pemphigus lesions［J］. J Invest Dermatol, 2021,141（9）:2141⁃2150. DOI: 10.1016/j.jid.2021.01.030.
［32］	Haughton RD, Herbert SM, Ji⁃Xu A, et al. Janus kinase inhibitors for alopecia areata: a narrative review［J］. Indian J Dermatol Venereol Leprol, 2023,89（6）:799⁃806. DOI: 10.25259/IJDVL_1093_2022.
［33］	Axel De Greef, Romane Thirion, Pierre⁃Dominique Ghislain, et al. Real⁃life effectiveness and tolerance of baricitinib for the treatment of severe alopecia areata with 1⁃year follow⁃up data［J］. Dermatol Ther,2023,13（11）:2869⁃2877. DOI:10.1007/s13555⁃023⁃01030⁃x.
［34］	Malhotra K, Madke B. An updated review on current treatment of alopecia areata and newer therapeutic options［J］. Int J Trichology, 2023,15（1）:3⁃12. DOI: 10.4103/ijt.ijt_28_21.
［35］	刘元香, 梁源, 赵欣荣, 等. JAK抑制剂治疗儿童重症斑秃5例［J］. 中华皮肤科杂志, 2023,56（9）:849⁃852. DOI: 10.35541/cjd.20220317.
［36］	Del Duca E, Ruano Ruiz J, Pavel AB, et al. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing［J］. Br J Dermatol, 2020,183（6）:1083⁃1093. DOI: 10.1111/bjd.19040.
［37］	Hashimoto K, Yamada Y, Fujikawa M, et al. Altered T cell subpopulations and serum anti⁃TYRP2 and tyrosinase antibodies in the acute and chronic phase of alopecia areata in the C3H/HeJ mouse model［J］. J Dermatol Sci, 2021,104（1）:21⁃29. DOI: 10. 1016/j.jdermsci.2021.09.001.

[1]	中国医师协会皮肤科医师分会中华医学会皮肤性病学分会中国医疗保健国际交流促进会皮肤医学分会中国罕见病联盟皮肤病学分会 . [开放获取] 斑块状银屑病生物制剂长程治疗管理专家共识（2026版）[J]. 中华皮肤科杂志, 2026, 59(9): 827-843.
[2]	唐祯刘宇航杨凌胡凌雪贺治杰曹凯丁澍. 反射式共聚焦显微镜在皮肤型红斑狼疮诊断与鉴别诊断中的价值及特征分析[J]. 中华皮肤科杂志, 2026, 59(9): 873-880.
[3]	陈星宇姚煦. 中性粒细胞在炎症性皮肤病中的研究进展[J]. 中华皮肤科杂志, 2026, 59(9): 905-910.
[4]	马静栾超陈崑. 脂代谢相关蛋白在银屑病中的研究进展[J]. 中华皮肤科杂志, 2026, 59(9): 915-918.
[5]	张寒梅冯素英. 肠道、皮肤和口腔菌群在自身免疫性水疱病中的研究进展[J]. 中华皮肤科杂志, 2026, 59(9): 902-905.
[6]	吉祥朱萍黄淑黛蒋佳怡黄凯旋李哲曦杨茜王大光. 自身免疫性大疱病住院患者并发静脉血栓栓塞的危险因素回顾分析[J]. 中华皮肤科杂志, 2026, 59(8): 779-782.
[7]	时熔灿, 余增洋, 罗清琼马蕊, 蒋星宇, 王媛媛, 蔡江鲁伊, 史玉玲, . 银屑病皮损的棕榈酰化组学特征及其在炎症反应中的作用初探[J]. 中华皮肤科杂志, 2026, 59(8): 738-749.
[8]	《脓疱型银屑病诊疗中国专家共识（版）》编写委员会专家组. [开放获取] 脓疱型银屑病诊疗中国专家共识（2026版）[J]. 中华皮肤科杂志, 2026, 59(8): 717-727.
[9]	魏瑾闫会文张建中伦文辉. 司库奇尤单抗治疗合并人类免疫缺陷病毒感染的中重度斑块状银屑病10例临床疗效观察[J]. 中华皮肤科杂志, 2026, 59(7): 671-674.
[10]	宇文天翊周子桢田竞宇陈思涵李敏张峰源顾恒陈旭. 角质形成细胞谷氨酰胺酶1/氨代谢轴在中波紫外线诱导的急性损伤和银屑病皮肤炎症中的表达研究[J]. 中华皮肤科杂志, 2026, 59(7): 654-661.
[11]	胡煜鲁严陈崑顾恒. [开放获取] 规范化、精准化与全周期管理：《白癜风患者家庭光疗管理规范》解读[J]. 中华皮肤科杂志, 2026, 59(7): 632-636.
[12]	中国康复医学会皮肤病康复专业委员会中国中西医结合学会皮肤性病专业委员会 . [开放获取] 老年银屑病诊疗与康复专家共识（2026版）[J]. 中华皮肤科杂志, 2026, 59(5): 407-418.
[13]	张笑旭罗素菊. 乌帕替尼治疗6例掌跖脓疱病的临床疗效与安全性分析[J]. 中华皮肤科杂志, 2026, 59(5): 459-463.
[14]	中华医学会皮肤性病学分会中国医师协会皮肤科医师分会中国医疗保健国际交流促进会皮肤医学分会中国罕见病联盟皮肤病学分会. [开放获取] 肠道菌群移植治疗银屑病专家共识（2026版）[J]. 中华皮肤科杂志, 2026, 59(5): 427-435.
[15]	中国“一带一路”皮肤病学专科联盟水疱病专病联盟中华医学会皮肤性病学分会天疱疮/大疱性类天疱疮研究协作组. 抗p200类天疱疮诊断与治疗专家共识（2026版）[J]. 中华皮肤科杂志, 2026, 59(5): 387-395.

组织常驻记忆T细胞在自身免疫性皮肤病复发中的作用

The role of tissue-resident memory T cells in the recurrence of autoimmune skin diseases

PDF

PDF (Mobile)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 37

相关文章 15

Metrics

本文评价

推荐阅读 10