口服益生菌治疗皮肤疾病的作用机制与应用进展

doi:10.35541/cjd.20240514

中华皮肤科杂志 ›› 2026, e20240514.doi: 10.35541/cjd.20240514

口服益生菌治疗皮肤疾病的作用机制与应用进展

代盈盈,王莲,蒋献

四川大学华西医院皮肤性病科四川大学疾病分子网络前沿科学中心免疫炎症研究院皮肤病学研究室，成都 610041

收稿日期:2024-09-26 修回日期:2026-06-23 发布日期:2026-09-22
通讯作者: 蒋献 E-mail:jiangxian@scu.edu.cn
基金资助:
四川大学华西医院院-企合作临床研究创新项目（2019HXCX010）；四川省自然科学基金项目（2023NSFSC1554）；国家自然科学基金（82273559）

Oral probiotics in the treatment of skin diseases: mechanisms of action and advances in their application

Dai Yingying, Wang Lian, Jiang Xian

Department of Dermatology and Venereology, Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China

Received:2024-09-26 Revised:2026-06-23 Published:2026-09-22
Contact: Jiang Xian E-mail:jiangxian@scu.edu.cn
Supported by:
Clinical Research Innovation Project, West China Hospital, Sichuan University （2019HXCX010）; Sichuan Natural Science Foundation （2023NSFSC1554）; National Natural Science Foundation of China （82273559）

摘要/Abstract

摘要： 【摘要】肠道菌群与皮肤健康密切相关，补充益生菌有助于调节肠道菌群，维持肠道微生态稳态。已有研究表明，乳杆菌属、双歧杆菌属等益生菌通过调节短链脂肪酸等代谢产物介导的免疫反应、神经内分泌功能和屏障结构等多种机制，对治疗皮肤疾病产生积极影响。本文综述口服益生菌改善皮肤健康的作用机制和其在特应性皮炎、银屑病、寻常痤疮等特定皮肤疾病治疗中的应用进展。

关键词: 皮肤疾病, 胃肠道微生物组, 益生菌, 短链脂肪酸, 肠-皮肤轴, 皮炎, 特应性, 银屑病, 寻常痤疮

Abstract: 【Abstract】 The gut microbiota is closely associated with skin health, and probiotic supplementation contributes to regulating the gut microbiota and maintaining gut homeostasis. Studies have shown that probiotics, such as Lactobacillus and Bifidobacterium, exert beneficial effects in the treatment of skin diseases through various mechanisms, including modulation of immune responses mediated by metabolites such as short-chain fatty acids, regulation of neuroendocrine functions, and enhancement of barrier structures. This review summarizes the mechanisms by which oral probiotics improve skin health and discusses the advances in their application in the treatment of specific skin diseases, including atopic dermatitis, psoriasis, and acne vulgaris.

Key words: Skin diseases, Gastrointestinal microbiome, Probiotics, Short-chain fatty acids, Gut-skin axis, Dermatitis, atopic, Psoriasis, Acne vulgaris

代盈盈王莲蒋献. 口服益生菌治疗皮肤疾病的作用机制与应用进展[J]. 中华皮肤科杂志, 2026,e20240514. doi:10.35541/cjd.20240514

Ying-Ying DAI Lian Wang XIAN JIANG. Oral probiotics in the treatment of skin diseases: mechanisms of action and advances in their application[J]. Chinese Journal of Dermatology,2026,e20240514. doi:10.35541/cjd.20240514

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口服益生菌治疗皮肤疾病的作用机制与应用进展

Oral probiotics in the treatment of skin diseases: mechanisms of action and advances in their application

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