核苷酸结合寡聚化结构域样受体蛋白3在雄激素性脱发发病中的作用及相关治疗进展

doi:10.35541/cjd.20250158

中华皮肤科杂志 ›› 2026, e20250158.doi: 10.35541/cjd.20250158

核苷酸结合寡聚化结构域样受体蛋白3在雄激素性脱发发病中的作用及相关治疗进展

黄金金¹ 李竹清² 卢娟娟^1，3 李淑华^1，3 曹哲^1，3 徐栋花¹ 王国颖^1，3

¹山东第二医科大学第一附属医院（潍坊市人民医院），潍坊 261000；²山东第二医科大学，潍坊 261000；3山东省医药卫生皮肤免疫重点实验室（潍坊市人民医院），潍坊 261000

收稿日期:2025-03-27 修回日期:2026-04-09 发布日期:2026-05-27
通讯作者: 王国颖 E-mail:Wfwgy2019@163.com
基金资助:
国家中医药管理局科技司共建科技项目（GZY-KJS-SD-2023-022）

Role of nucleotide-binding oligomerization domain-like receptor protein 3 in the pathogenesis of androgenetic alopecia and therapeutic advances

Huang Jinjin¹, Li Zhuqing², Lu Juanjuan^1，3, Li Shuhua^1，3, Cao Zhe^1，3, Xu Donghua¹, Wang Guoying^1，3#br#

¹The First Affiliated Hospital of Shandong Second Medical University （Weifang People's Hospital）, Weifang 261000, China; ²Shandong Second Medical University, Weifang People's Hospital, Weifang 261000, China; 3Shandong Key Laboratory of Medicine and Health Skin Immunity （Weifang People's Hospital）, Weifang 261000, China

Received:2025-03-27 Revised:2026-04-09 Published:2026-05-27
Contact: Wang Guoying E-mail:Wfwgy2019@163.com
Supported by:
Collaborative Science and Technology Project of the Department of Science and Technology, National Administration of Traditional Chinese Medicine（GZY-KJS-SD-2023-022）

摘要/Abstract

摘要： 【摘要】雄激素性脱发（AGA）主要表现为毛囊微型化和毛发稀疏，病理机制涉及雄激素代谢异常、毛囊微环境炎症及免疫失衡。有研究显示，核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）炎症小体过度激活及肠道菌群-脑轴失衡与AGA发病密切相关。本文综述NLRP3炎症小体与肠道菌群-脑轴在AGA病理进程中的作用机制，以及靶向NLRP3免疫调节治疗AGA的策略，旨在提升AGA的治疗水平。

关键词: 秃发, NLR家族, 热蛋白结构域包含蛋白3, 胃肠道微生物组, 肠道菌群-脑轴, 脂肪干细胞外泌体, 生发饮

Abstract: 【Abstract】 Androgenetic alopecia （AGA） is mainly characterized by hair follicle miniaturization and hair thinning. Its pathogenesis involves abnormal androgen metabolism, inflammation of the hair follicle microenvironment, and immune imbalance. Studies have shown that excessive activation of the nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） inflammasome and imbalance of the gut microbiota-brain axis are closely associated with the development of AGA. This article reviews the mechanisms of the NLRP3 inflammasome and the gut microbiota-brain axis in the pathological progression of AGA, as well as therapeutic strategies targeting NLRP3-mediated immunomodulation for the treatment of AGA, with the aim of improving therapeutic outcomes.

Key words: Alopecia, NLR family, pyrin domain-containing 3 protein, Gastrointestinal microbiome, Gut microbiota-brain axis, Adipose-derived stem cell exosomes, Shengfa Yin

黄金金李竹清卢娟娟李淑华曹哲徐栋花王国颖. 核苷酸结合寡聚化结构域样受体蛋白3在雄激素性脱发发病中的作用及相关治疗进展[J]. 中华皮肤科杂志, 2026,e20250158. doi:10.35541/cjd.20250158

Huang Jinjin, Li Zhuqing, Lu Juanjuan, Li Shuhua, Cao Zhe, Xu Donghua, Wang Guoying, . Role of nucleotide-binding oligomerization domain-like receptor protein 3 in the pathogenesis of androgenetic alopecia and therapeutic advances[J]. Chinese Journal of Dermatology,2026,e20250158. doi:10.35541/cjd.20250158

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核苷酸结合寡聚化结构域样受体蛋白3在雄激素性脱发发病中的作用及相关治疗进展

Role of nucleotide-binding oligomerization domain-like receptor protein 3 in the pathogenesis of androgenetic alopecia and therapeutic advances

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