中华皮肤科杂志 ›› 2023, e20220036.doi: 10.35541/cjd.20220036

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自噬在毛发生理病理中的研究进展

孙佳怡    宋秀祖   

  1. 浙江中医药大学附属杭州第三医院  杭州市第三人民医院皮肤科,杭州  310009
  • 收稿日期:2022-01-14 修回日期:2023-03-12 发布日期:2023-11-21
  • 通讯作者: 宋秀祖 E-mail:songxiuzu@sina.com
  • 基金资助:
    国家自然科学基金(81872517)

Autophagy in hair physiology and pathology

Sun Jiayi, Song Xiuzu   

  1. Department of Dermatology, Hangzhou Third People′s Hospital, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China
  • Received:2022-01-14 Revised:2023-03-12 Published:2023-11-21
  • Contact: Song Xiuzu E-mail:songxiuzu@sina.com
  • Supported by:
    National Natural Science Foundation of China(81872517)

摘要: 【摘要】 自噬是细胞适应和存活的重要机制,自噬在正常生理条件下激活毛囊干细胞,诱导毛发周期从休止期进入生长期,维持毛发生长周期,在病理条件下保护毛乳头细胞抵抗损伤。雄激素性脱发和斑秃等脱发疾病中存在自噬受损,干预自噬可延缓脱发进展。本文综述自噬在调节毛发周期、维持细胞稳态、促进毛发再生中的作用,为靶向自噬信号通路的脱发药物筛选提供新思路。

关键词: 自噬, 毛囊, 脱发, 雄激素性脱发, 斑秃

Abstract: 【Abstract】 Autophagy is the essential mechanism for cell adaptation and survival. Under normal physiological conditions, autophagy activates hair follicle stem cells, induces the transition of hair follicles from the telogen phase to the anagen phase, and maintains the hair growth cycle. Moreover, autophagy can protect dermal papilla cells from damage under pathological conditions. Intervention in autophagy can slow the progress of hair loss due to the existence of impaired autophagy in androgenetic alopecia and alopecia areata. The review summarizes the role of autophagy in hair cycle regulation, cell homeostasis maintenance, and hair regeneration, providing new insights into therapeutic options targeting follicular autophagy signaling pathways.

Key words: Autophagy, Hair follicle, Hair loss, Androgenetic alopecia, Alopecia areata

引用本文

孙佳怡 宋秀祖. 自噬在毛发生理病理中的研究进展[J]. 中华皮肤科杂志, 2023,e20220036. doi:10.35541/cjd.20220036

Sun Jiayi, Song Xiuzu. Autophagy in hair physiology and pathology[J]. Chinese Journal of Dermatology,2023,e20220036. doi:10.35541/cjd.20220036