毛囊生长周期调控的机制进展

doi:10.35541/cjd.20230226

中华皮肤科杂志 ›› 2025, Vol. 58 ›› Issue (7): 686-690.doi: 10.35541/cjd.20230226

毛囊生长周期调控的机制进展

陈钰虹吕中法

浙江大学医学院附属第二医院皮肤科，杭州 310009

收稿日期:2023-04-20 修回日期:2024-06-06 发布日期:2025-07-03
通讯作者: 吕中法 E-mail:lzfskin@zju.edu.cn
基金资助:
国家自然科学基金（81972959、82273553）

Regulatory mechanisms underlying the hair cycle

Chen Yuhong, Lyu Zhongfa

Department of Dermatology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China

Received:2023-04-20 Revised:2024-06-06 Published:2025-07-03
Contact: Lyu Zhongfa E-mail:lzfskin@zju.edu.cn
Supported by:
National Natural Science Foundation of China（81972959、82273553）

摘要/Abstract

摘要： 【摘要】毛囊是皮肤附属器，具有复杂精细的结构和周期性自我更新能力。毛囊生长周期包括生长期、退行期和休止期，其有序更新对维持毛发生长具有重要意义。目前认为Wnt、骨形态发生蛋白、Notch等信号通路参与毛囊生长周期的调控。随着研究的深入，基于上述信号通路的各类调控方式被逐步揭示，如生长因子、非编码RNA、免疫反应等。本文阐述相关分子机制和调控方式，为深入了解毛囊生长周期的调控机制和拓展脱发治疗手段提供理论参考。

关键词: 毛囊, 秃发, 毛囊生长周期, 信号通路, 成纤维细胞生长因子

Abstract: 【Abstract】 Hair follicles are skin appendages with a complex structure and periodically self-renewal ability. The hair cycle includes the anagen phase, catagen phase and telogen phase, and its orderly renewal is important to maintain hair growth. It is currently believed that Wnt, bone morphogenetic protein, and Notch signaling pathways are involved in regulating the hair cycle. As research progresses, various regulatory mechanisms based on these signaling pathways have been gradually revealed, such as growth factors, non-coding RNAs, immune responses, etc. This review elaborates on the above molecular mechanisms and regulatory modalities, aiming to better understand regulatory mechanisms underlying the hair cycle and provide a theoretical reference for expanding treatment options for hair loss.

Key words: Hair follicle, Alopecia, Hair cycle, Signaling pathway, Fibroblast growth factors

陈钰虹吕中法. 毛囊生长周期调控的机制进展[J]. 中华皮肤科杂志, 2025,58(7):686-690. doi:10.35541/cjd.20230226

Chen Yuhong, Lyu Zhongfa. Regulatory mechanisms underlying the hair cycle[J]. Chinese Journal of Dermatology, 2025, 58(7): 686-690.doi:10.35541/cjd.20230226

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毛囊生长周期调控的机制进展

Regulatory mechanisms underlying the hair cycle

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