单细胞测序在毛发相关研究中的应用

doi:10.35541/cjd.20230292

中华皮肤科杂志 ›› 2024, e20230292.doi: 10.35541/cjd.20230292

单细胞测序在毛发相关研究中的应用

杨洁,刘莉萍

江苏大学附属医院皮肤科江苏大学再生医学研究院，镇江 212001

收稿日期:2023-05-23 修回日期:2024-04-18 发布日期:2024-09-29
通讯作者: 刘莉萍 E-mail:liuliping@ujs.edu.cn
基金资助:
国家自然科学基金项目（82103766）；江苏省医学重点学科建设单位（JSDW202229）

Application of single-cell sequencing in the hair research

Yang Jie, Liu Liping

Department of Dermatology & Jiangsu University Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu Hospital, Zhenjiang 212001, Jiangsu, China

Received:2023-05-23 Revised:2024-04-18 Published:2024-09-29
Contact: Liu Liping E-mail:liuliping@ujs.edu.cn
Supported by:
National Natural Science Foundation of China （82103766）; Jiangsu Provincial Medical Key Discipline Cultivation Unit （JSDW202229）

摘要/Abstract

摘要： 【摘要】毛囊是由多种类型细胞组成的复杂器官。单细胞测序技术可在单细胞水平上识别组织中各种类型及亚群细胞的转录特征，全面揭示细胞群间的异质性。本综述回顾了采用单细胞测序研究小鼠和人类毛囊细胞的分子特征和命运调控及其在衰老、菌群共生以及脱发和白发发生机制的最新进展。单细胞测序为研究毛囊的形态发生、细胞类型和生理及病理状态提供了一种全新工具，揭示了传统研究中没有发现的重要信息，对于毛发相关研究具有重要意义。

关键词: 毛发, 毛囊, 序列分析, DNA, 单细胞测序, 秃发, 白发

Abstract: 【Abstract】 Hair follicles are complex organs consisting of multiple cell types. Single-cell sequencing technology can identify the transcriptional characteristics of various cell types and subsets in tissues at the single-cell level, comprehensively revealing the heterogeneity among cell populations. This review focuses on the latest advances in the application of single-cell sequencing to the study of molecular characteristics of mouse and human hair follicle cells and cell fate regulation, as well as aging, microbial symbiosis, and the pathogenesis of hair loss and hair graying. Single-cell sequencing can serve as a novel tool for studying the morphogenesis, cell types, physiological and pathological states of hair follicles. It reveals important information that has not been found in traditional research, and is meaningful for hair-related studies.

Key words: Hair, Hair follicle, Sequence analysis, DNA, Single-cell sequencing, Alopecia, Hair graying

杨洁刘莉萍. 单细胞测序在毛发相关研究中的应用[J]. 中华皮肤科杂志, 2024,e20230292. doi:10.35541/cjd.20230292

Yang Jie, Liu Liping. Application of single-cell sequencing in the hair research[J]. Chinese Journal of Dermatology,2024,e20230292. doi:10.35541/cjd.20230292

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单细胞测序在毛发相关研究中的应用

Application of single-cell sequencing in the hair research

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