中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (2): 113-116.doi: 10.35541/cjd.20190759

• 论著 • 上一篇    下一篇

女性外阴慢性单纯性苔藓的临床研究

高小曼    李明    杨敏    文玮    孙凯律    常建民    傅裕   

  1. 北京医院皮肤科  国家老年医学中心  中国医学科学院老年医学研究院  100730
  • 收稿日期:2019-07-23 修回日期:2019-12-10 发布日期:2020-02-01
  • 通讯作者: 傅裕 E-mail:13601326358@163.com

Clinical analysis of vulvar lichen simplex chronicus

Gao Xiaoman, Li Ming, Yang Min, Wen Wei, Sun Kailyu, Chang Jianmin, Fu Yu   

  1. Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2019-07-23 Revised:2019-12-10 Published:2020-02-01
  • Contact: Fu Yu E-mail:13601326358@163.com

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摘要： 【摘要】 目的 分析女性外阴慢性单纯性苔藓（VLSC）的临床特征。方法 回顾分析2017—2018年就诊于北京医院皮肤科外阴专病门诊的137例VLSC患者的临床特征。不符合正态分布的计量资料（年龄、病程）以M（P25，P75）表示，采用秩和检验比较，计数资料的比较采用χ2检验。结果 137例患者发病年龄32.0（25.5，40.0）岁，病程36.0（15.0，72.0）个月。32例（23.4%）有特应性疾病史，其VLSC发病年龄［29.5（25.0，35.8）］早于无特应性疾病患者［33.0（27.0，41.0），Z = 2.03，P = 0.042］。皮损特征方面，130例（94.9%）累及大阴唇，13例（9.5%）累及小阴唇，103例（75.2%）皮损双侧分布，8例（5.8%）出现色素减退。所有患者均有不同程度瘙痒，中度瘙痒44例（32.1%）、重度80例（58.4%），重度瘙痒患者占病程 > 2年患者的比例（68.1%）高于病程 < 2年的患者（47.7%），差异有统计学意义（χ2 = 5.83，P = 0.016）。患者自觉诱发瘙痒加重因素包括，局部潮湿出汗（55例，40.1%）、进食辛辣刺激食物（41例，29.9%）、精神紧张（36例，26.3%）。结论 VLSC好发于20 ~ 39岁，特应性体质可能是重要病因，主要累及大阴唇，多双侧分布，病程越长瘙痒越严重。

关键词: 神经性皮炎, 外阴疾病, 瘙痒症, 女性, 色素减退, 局部潮湿

Abstract: 【Abstract】 Objective To investigate clinical features of vulvar lichen simplex chronicus （VLSC）. Methods Clinical data were collected from 137 VLSC patients who visited a Vulvar Clinic in the Department of Dermatology, Beijing Hospital from 2017 to 2018, and analyzed retrospectively. Non-normally distributed measurement data （age and disease duration） were described as median （P25, P75）, and analyzed by using rank sum test, and enumeration data were compared by using chi-square test. Results Among the 137 patients with VLSC, the age at onset was 32.0 （25.5, 40.0） years, and the disease duration was 36.0 （15.0, 72.0） months. Thirty-two （23.4%） patients had a history of atopic diseases, and the age at onset of VLSC was significantly lower in these patients with a history of atopic diseases （29.5 ［25.0, 35.8］ years） than in those without a history of atopic diseases （33.0 ［27.0, 41.0］ years, Z = 2.03, P = 0.042）. The most frequently involved site was the labia majora （130/137, 94.9%）, and the labia minora was rarely involved （13/137, 9.5%）. Bilateral lesions were observed in 103 （75.2%） patients, and hypopigmentation occurred in 8 （5.8%） patients. All the patients experienced itching to different extents, including moderate itching in 44 （32.1%） cases and severe itching in 80 （58.4%）. The ratio of patients with severe itching to those with disease duration > 2 years （68.1%） was significantly higher than that of patients with severe itching to those with disease duration < 2 years （47.7%, χ2 = 5.830, P = 0.016）. Patients reported that local wetness and sweating （55 cases, 40.1%）, spicy diet （41 cases, 29.9%） and mental stress （36 cases, 26.3%） could aggravate itching. Conclusions VLSC commonly occurs in patients aged 20 - 39 years, and atopic predisposition may be an important factor for VLSC. VLSC mostly involves bilateral labia majora, and the longer the disease duration, the more severe the itching.

Key words: Neurodermatitis, Vulvar diseases, Pruritus, Femininity, Hypopigmentation, Local wetness

引用本文

高小曼 李明 杨敏 文玮 孙凯律 常建民 傅裕. 女性外阴慢性单纯性苔藓的临床研究[J]. 中华皮肤科杂志, 2020,53(2):113-116. doi:10.35541/cjd.20190759

Gao Xiaoman, Li Ming, Yang Min, Wen Wei, Sun Kailyu, Chang Jianmin, Fu Yu. Clinical analysis of vulvar lichen simplex chronicus[J]. Chinese Journal of Dermatology, 2020, 53(2): 113-116.doi:10.35541/cjd.20190759