中华皮肤科杂志 ›› 2024, Vol. 57 ›› Issue (5): 475-478.doi: 10.35541/cjd.20210582

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治疗瘙痒的小分子/生物制剂药物研究进展

郭澜 晋红中   

  1. 中国医学科学院  北京协和医学院北京协和医院皮肤科  疑难重症及罕见病国家重点实验室  国家皮肤与免疫疾病临床医学研究中心,北京  100730
  • 收稿日期:2021-08-11 修回日期:2022-05-06 发布日期:2024-04-30
  • 通讯作者: 晋红中 E-mail:jinhongzhong@263.net
  • 基金资助:
    国家自然科学基金(82073450);中央高水平医院临床科研专项(2022-PUMCH-B-092)

Small-molecule/biological agents in the treatment of pruritus

Guo Lan, Jin Hongzhong   

  1. Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, China
  • Received:2021-08-11 Revised:2022-05-06 Published:2024-04-30
  • Contact: Jin Hongzhong E-mail:jinhongzhong@263.net
  • Supported by:
    National Natural Science Foundation of China(82073450); National High‐Level Hospital Clinical Research Funding (2022-PUMCH-B-092)

摘要: 【摘要】 近年来,皮肤瘙痒发病机制的研究有了较大进展,开发了许多新型靶向治疗药物,主要包括针对参与瘙痒信号传导通路如神经激肽受体1、原肌球蛋白相关激酶A、瞬时受体电位香草酸亚型1、瞬时受体电位M8通道、白细胞介素31等的小分子药物或生物制剂。部分药物对多种皮肤病的瘙痒治疗有良好的有效性和安全性,为瘙痒患者尤其是对传统药物治疗抵抗的患者提供了更多选择。本综述总结以上针对瘙痒信号传导通路的小分子及生物制剂药物的研究进展,以期为瘙痒治疗提供更多的方法。

关键词: 瘙痒症, 生物制剂, 信号转导, 小分子抑制剂

Abstract: 【Abstract】 In recent years, great progress has been made in the research on the pathogenesis of pruritus, and many new targeted therapeutic drugs have been developed, mainly including small-molecule drugs or biological agents targeting signal transduction pathways involved in the pathogenesis of pruritus, such as neurokinin-1 receptor, tropomyosin-related kinase A, transient receptor potential vanilloid 1, transient receptor potential melastatin 8 channels, interleukin 31, etc. Some of these drugs have shown good efficacy and safety in the treatment of pruritus in a variety of skin diseases, providing more options for patients with pruritus, especially those who are resistant to traditional drug treatment. This review summarizes research progress in the above small-molecule drugs and biological agents targeting signaling pathways involved in pruritus, in order to provide more options for pruritus treatment.

Key words: Pruritus, Biological agents, Signal transduction, Small molecule inhibitors

引用本文

郭澜 晋红中. 治疗瘙痒的小分子/生物制剂药物研究进展[J]. 中华皮肤科杂志, 2024,57(5):475-478. doi:10.35541/cjd.20210582

Guo Lan, Jin Hongzhong. Small-molecule/biological agents in the treatment of pruritus[J]. Chinese Journal of Dermatology, 2024, 57(5): 475-478.doi:10.35541/cjd.20210582