中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (2): 109-112.doi: 10.35541/cjd.20190746

• 论著 • 上一篇    下一篇

抗γ干扰素自身抗体阳性伴Sweet综合征的马尔尼菲篮状菌病九例临床分析

付玉姣    郭静    史娜娜    宁心强    韦芳林    郑艳青    郑冬燕    曹存巍   

  1. 广西医科大学第一附属医院皮肤性病科，南宁  530021
  • 收稿日期:2019-07-16 修回日期:2019-11-17 发布日期:2020-02-01
  • 通讯作者: 曹存巍 E-mail:caocunwei@yeah.net
  • 基金资助:
    国家自然科学基金（81571971）；广西自然科学基金（AB18221017、2018GXNSFAA 294090）

Clinical analysis of nine anti-interferon-γ autoantibody-positive patients with talaromycosis marneffei complicated by Sweet syndrome

Fu Yujiao, Guo Jing, Shi Nana, Ning Xinqiang, Wei Fanglin, Zheng Yanqing, Zheng Dongyan, Cao Cunwei    

  1. Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China 
  • Received:2019-07-16 Revised:2019-11-17 Published:2020-02-01
  • Contact: Cao Cunwei E-mail:caocunwei@yeah.net
  • Supported by:
    National Natural Science Foundation of China （81571971）;  Natural Science Foundation of Guangxi Province of China （AB18221017, 2018GXNSFAA294090）

PDF

16

摘要： 【摘要】 目的 报道9例HIV阴性伴Sweet综合征的马尔尼菲篮状菌病（TSM），及其与抗γ干扰素自身抗体的关系。方法 回顾分析广西医科大学第一附属医院2013—2018年确诊的HIV阴性伴Sweet综合征TSM患者的临床资料。以19例HIV阳性TSM患者及107例健康人为对照，检测外周血抗γ干扰素自身抗体。结果 9例中男5例，女4例，TSM发病年龄38 ~ 60岁。患者均呈播散性感染，临床表现为长期不规则发热、多部位淋巴结肿大、咳嗽、消瘦、贫血。9例均符合经典型Sweet综合征的诊断标准，Sweet综合征皮疹微生物学检查阴性。除马尔尼菲篮状菌感染之外，还合并非结核分支杆菌（6例）、水痘-带状疱疹病毒（4例）、沙门氏菌（2例）感染。患者组9例外周血抗γ干扰素自身抗体检测结果均阳性，而107例健康人及19例HIV阳性TSM患者均阴性。结论 抗γ干扰素自身抗体阳性可能与HIV阴性伴Sweet综合征的TSM相关。

关键词: Sweet综合征, 干扰素γ, HIV, 真菌病, 马尔尼菲篮状菌病

Abstract: 【Abstract】 Objective To report 9 HIV-negative patients with talaromycosis marneffei （TSM） complicated by Sweet syndrome, and to analyze the relationship of the anti-interferon-γ （anti-IFN-γ） autoantibody with TSM complicated by Sweet syndrome. Methods HIV-negative patients with TSM complicated by Sweet syndrome were collected from the First Affiliated Hospital of Guangxi Medical University between 2013 and 2018. Their clinical and laboratory data were analyzed retrospectively. Meanwhile, 19 HIV-positive patients with TSM and 107 health checkup examinees served as controls. Anti-IFN-γ autoantibody was detected in peripheral blood samples of the patients and controls. Results A total of 9 HIV-negative patients with TSM (5 males and 4 females) were included in this study, and the age of onset ranged from 38 to 60 years. The 9 patients all presented with disseminated infections, manifesting as long-term irregular fever, multiple lymph node enlargement, cough, emaciation and anemia. All of the 9 patients met the diagnostic criteria for classical Sweet syndrome, and microbiological examination of Sweet syndrome lesions was negative. Besides Talaromyces marneffei, 6 patients also were infected with nontuberculous mycobacteria, 4 with varicella-zoster virus, and 2 with Salmonella. All the 9 HIV-negative patients with TSM were positive for anti-IFN-γ autoantibody, while the 107 healthy controls and 19 HIV-positive patients with TSM were negative for anti-IFN-γ autoantibody. Conclusion Anti-IFN-γ autoantibody may be associated with HIV-negative TSM complicated by Sweet syndrome.

Key words: Sweet syndrome, Interferon-gamma, HIV, Mycoses, Talaromycosis marneffei 

引用本文

付玉姣 郭静 史娜娜 宁心强 韦芳林 郑艳青 郑冬燕 曹存巍. 抗γ干扰素自身抗体阳性伴Sweet综合征的马尔尼菲篮状菌病九例临床分析[J]. 中华皮肤科杂志, 2020,53(2):109-112. doi:10.35541/cjd.20190746

Fu Yujiao, Guo Jing, Shi Nana, Ning Xinqiang, Wei Fanglin, Zheng Yanqing, Zheng Dongyan, Cao Cunwei . Clinical analysis of nine anti-interferon-γ autoantibody-positive patients with talaromycosis marneffei complicated by Sweet syndrome[J]. Chinese Journal of Dermatology, 2020, 53(2): 109-112.doi:10.35541/cjd.20190746