Chinese Journal of Dermatology ›› 2024, Vol. 57 ›› Issue (10): 962-966.doi: 10.35541/cjd.20220709

• Reviews • Previous Articles    

Application of crisaborole ointment in dermatology

Yang Siyan1, Ma Lin2, Zhang Bin2   

  1. 1Department of Dermatology, Henan Clinical Research Center of Childhood Diseases, Children′s Hospital Affiliated of Zhengzhou University, Henan Children′s Hospital Zhengzhou Children′s Hospital, Zhengzhou 450018, China; 2Department of Dermatology, Beijing Children′s Hospital, Capital Medical University, National Center for Children′s Health, Beijing 100045, China
  • Received:2022-10-11 Revised:2023-12-19 Online:2024-10-15 Published:2024-09-29
  • Contact: Zhang Bin;Ma Lin E-mail:dr.binzhang@163.com; bch_maleen@aliyun.com
  • Supported by:
    Beijing Natural Science Foundation (7222058); Open Project of Henan Clinical Research Center of Childhood Diseases (YJZX202209); National Regional Medical Center Opening Project (NRMC0101)

Abstract: 【Abstract】 Crisaborole ointment, a phosphodiesterase-4 inhibitor, has been approved for the treatment of mild to moderate atopic dermatitis in China. In addition, crisaborole has been reported for the successful treatment of other inflammatory skin disorders. This review summarizes mechanisms of action of crisaborole and its application to the treatment of atopic dermatitis, psoriasis, vitiligo, seborrheic dermatitis, inflammatory linear verrucous epidermal nevus, lichen simplex chronicus, prurigo pigmentosa, alopecia areata, plasma cell balanitis, and lichen planus.

Key words: Cyclic nucleotide phosphodiesterases, type 4, Phosphodiesterase-4 inhibitor, Crisaborole ointment, Skin diseases, Therapy, Dermatitis, atopic, Psoriasis, Vitiligo