缺氧诱导因子1α在自身免疫性皮肤病中的研究进展

doi:10.35541/cjd.20250202

Abstract

Abstract: 【Abstract】 Hypoxia-inducible factor 1α (HIF-1α), a highly conserved transcription factor, plays an important role in responding to changes in oxygen levels, cellular metabolism, and the regulation of cytokines and immune cell functions. Increasing evidence has demonstrated that HIF-1α plays a critical role in autoimmune skin diseases, including psoriasis, atopic dermatitis, systemic lupus erythematosus, alopecia areata, vitiligo, and systemic sclerosis. This article reviews the research progress on HIF-1α in autoimmune skin diseases and discusses its future research prospects and potential applications in dermatology.

Key words: Hypoxia-inducible factor 1, alpha Subunit, Autoimmune dermatosis, Psoriasis, Dermatitis, atopic, Lupus erythematosus, systemic, Alopecia areata, Vitiligo, Scleroderma, systemic

Chen Ruolin, Cao Yan. Hypoxia-inducible factor-1α in autoimmune skin diseases[J]. Chinese Journal of Dermatology,2026,e20250202. doi:10.35541/cjd.20250202

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Hypoxia-inducible factor-1α in autoimmune skin diseases

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