Chinese Journal of Dermatology ›› 2025, Vol. 58 ›› Issue (12): 1192-1195.doi: 10.35541/cjd.20220795

• Reviews • Previous Articles    

Application of biological therapies and mechanisms of immunophenotypic switching in psoriasis and atopic dermatitis

Ye Hui, Xue Rujun, Zhang Xibao   

  1. Institute of Dermatology, Guangzhou Medical University, Guangzhou Dermatology Hospital, Guangzhou 510095, China
  • Received:2022-11-10 Revised:2023-06-08 Online:2025-12-15 Published:2025-12-04
  • Contact: Zhang Xibao E-mail:zxibao@126.com
  • Supported by:
    Science and Technology Program of Guangzhou(2023A03J0944)

Abstract: 【Abstract】 Biologic therapies have been successfully applied in the treatment of psoriasis and atopic dermatitis, however, unique phenomena of immunophenotypic switching have also been constantly reported. This review summarizes the current status and mechanisms of immunophenotypic switching among patients with psoriasis or atopic dermatitis during the treatment with biologics, in order to promote the full understanding of this new abnormal immune reaction.

Key words: Psoriasis, Dermatitis, atopic, Biological agents, Eczema, Immunophenotypic switching