新型G蛋白偶联受体X2在皮肤科的研究进展

doi:10.35541/cjd.20240124

Abstract

Abstract: 【Abstract】 Mast cells play a role in allergic reactions by secreting a variety of inflammatory mediators. The classical pathway of mast cell activation is mediated by high-affinity IgE receptors. In recent years, the Mas-related G protein-coupled receptor X2 （MRGPRX2） has been identified as the receptor responsible for non-IgE mediated mast cell activation. This review mainly summarizes the research progress in the role of the MRGPRX2 receptor in chronic urticaria, atopic dermatitis, allergic contact dermatitis, pseudoallergic reactions, rosacea, and other skin diseases.

Key words: G-protein-coupled receptor kinases, Mast cells, Urticaria, Dermatitis, atopic, Dermatitis, allergic contact, MRGPRX2, Rosacea, Pseudoallergic drug reaction

He Xingyan, Zhang Kejia, Feng Yanyan. Noval G protein-coupled receptor X2 in dermatology[J]. Chinese Journal of Dermatology,2024,e20240124. doi:10.35541/cjd.20240124

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Noval G protein-coupled receptor X2 in dermatology

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