Chinese Journal of Dermatology ›› 2024, e20230310.doi: 10.35541/cjd.20230310

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Correlations of gut microbiota and short-chain fatty acids with chronic spontaneous urticaria

Enze LI1,Lu CHEN2,Chu-Qiao ZHANG1, 2,Jiao qingqingJI Jiang   

  1. 1Department of Dermatology and Venereology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China; 2Department of Dermatology and Venereology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China
  • Received:2023-06-02 Revised:2023-11-27 Online:2024-01-29 Published:2024-02-02
  • Contact: Ji Jiang E-mail:jijiang2222@126.com
  • Supported by:
    National Natural Science Foundation of China(82073434)

Abstract: 【Abstract】 Autoimmunity and the activation of immune cells are closely related to the occurrence of chronic spontaneous urticaria. while the gut microbiota participates in multiple physiological activities including the regulation of the host′s immunity. Gut microbiota in patients with chronic spontaneous urticaria has unique structural composition and metabolic features. Gut microbiota imbalance and secondary short-chain fatty acid deficiency may be important causes for the occurrence of the disease and aggravation of inflammation. Studies have shown that probiotics can improve the clinical manifestations of patients with urticaria. This review summarizes the research progress in the correlations of gut microbiota and short-chain fatty acids with chronic spontaneous urticaria.

Key words: Urticaria, Chronic spontaneous urticaria, Gut microbiota, Short-chain fatty acids