Chinese Journal of Dermatology ›› 2020, Vol. 53 ›› Issue (4): 308-311.doi: 10.35541/cjd.20190082

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An overview of correlations between intestinal flora imbalance and common connective tissue diseases in dermatology

Yu Yao1, Han Yumei2, Zhou Jinzhe3, Li Lanying1   

  1. 1Department of Dermatology, Shanghai Fourth People′s Hospital, Shanghai 200080, China; 2Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai 200030, China; 3Department of General Surgery, Shanghai Tenth People′s Hospital, Shanghai 200040, China
  • Received:2018-12-03 Revised:2019-06-17 Online:2020-04-15 Published:2020-04-01
  • Contact: Li Lanying E-mail:Sy-lly@hotmail.com

Abstract: 【Abstract】 More and more studies have found that intestinal flora is associated with connective tissue diseases. This review summarizes characteristics of intestinal flora and its mechanism of action in connective tissue diseases, and mainly elaborates correlations between intestinal flora imbalance and 3 common connective tissue diseases (lupus erythematosus, systemic scleroderma and Sjogren′s syndrome), its possible mechanism of action and related hypothesis. Probiotics can regulate the intestinal flora imbalance, and serve as one of treatments for these common connective tissue diseases.

Key words: Lupus erythematosus, systemic, Scleroderma, systemic, Sjogren′s syndrome, Microbial consortia, Intestinal microbiota