Chinese Journal of Dermatology ›› 2019, Vol. 52 ›› Issue (5): 346-349.doi: 10.3760/cma.j.issn.0412-4030.2019.05.015

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Important skin microbiota associated with the occurrence of acne

Liu Yuzhen, Zeng Rong, Xu Haoxiang, Li Min   

  1. Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases, Nanjing 210042, China
  • Received:2018-05-09 Revised:2018-12-14 Online:2019-05-15 Published:2019-04-30
  • Contact: Xu Haoxiang; Li Min E-mail:249402842@qq.com; drlimin@sina.cn
  • Supported by:
    National Natural Science Foundation of China (81502739); Natural Science Foundation of Jiangsu Province of China (BK20150068); CAMS Innovation Fund for Medical Sciences (2017-I2M-1-017); PUMC Youth Fund (3332016108)

Abstract: 【Abstract】 Skin microbiota begin to form shortly after birth, with a wide variety and huge quantity, and are closely related to skin health. Acne is a common skin disorder associated with microbial infections. Propionibacterium acnes, Staphylococcus, Malassezia, etc., are three species of microorganisms currently known to be most closely associated with the occurrence of acne. This review summarizes the relationship between the above three species of microorganisms and the occurrence of acne, and mainly includes the pathogenicity of bacteria or fungi of different types, the relationship between these bacteria or fungi and the pathogenesis of acne, the difference in host immune responses induced by these bacteria or fungi, so as to provide evidence for developing new strategies for the treatment of acne.

Key words: Acne vulgaris, Microbial consortia, Propionibacterium acnes, Staphylococcus, Malassezia