Abstract: 【Abstract】 Objective To evaluate associations of psoriasis with adverse pregnancy outcomes. Methods Databases, including CNKI, Wanfang, VIP, PubMed, Embase and Cohrane Library databases, were searched for published articles on associations between psoriasis and adverse pregnancy outcomes between January 1980 and December 2018. Quality of included articles was assessed by using MOOSE checklist. Statistical analysis was carried out with Review Manager 5.3 software. Results One cohort study, 4 case-control studies and 2 cross-sectional studies meet the inclusion criteria. After heterogeneity test, meta-analysis was carried out by using a random effect model. The risks of cesarean （OR = 1.17, 95% CI: 1.01 - 1.37）, eclampsia or preeclampsia （OR = 1.34, 95% CI: 1.00 - 1.79）and premature birth （OR = 1.09, 95% CI: 1.00 - 1.19） were significantly higher in patients with psoriasis than in individuals without psoriasis （all P < 0.05）. There was no significant difference between patients with psoriasis and individuals without psoriasis in the risks of spontaneous abortion, low birth weight, high birth weight, stillbirth, congenital malformation, placental abruption, overdue delivery, low Apgar score （< 7）, polyhydramnios and oligohydramnios. Conclusion The risks of cesarean, eclampsia or preeclampsia, and premature birth are higher in patients with psoriasis than in individuals without psoriasis.

Key words: Psoriasis, Pregnancy outcome, Cesarean section, Eclampsia, Premature birth