Chinese Journal of Dermatology ›› 2023, Vol. 56 ›› Issue (8): 799-802.doi: 10.35541/cjd.20201257

• Reviews • Previous Articles    

Metformin in the treatment of psoriasis

Chen Xiaomin, Zhang Jingzhan, Ding Yuan, Kang Xiaojing   

  1. Department of Dermatology and Venereology, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
  • Received:2020-12-31 Revised:2021-12-12 Online:2023-08-15 Published:2023-08-07
  • Contact: Ding Yuan; Kang Xiaojing;
  • Supported by:
    Hospital-Level Project of People′s Hospital of Xinjiang Uygur Autonomous Region(20190106)

Abstract: 【Abstract】 Metformin, the first-line treatment of type 2 diabetes, has been also increasingly used in the treatment of some skin diseases, such as psoriasis. This review summarizes therapeutic mechanisms of and clinical research progress in metformin in the treatment of psoriasis, aiming to provide ideas and methods for the treatment of psoriasis, especially psoriasis complicated by metabolic diseases.

Key words: Psoriasis, Metformin, Therapy, NF-kappa B, Mechanistic target of rapamycin, Extracellular signal-regulated kinase, Signal transducing activator of transcription, Nucleotide-binding oligomerization domain-like receptor protein 3