Abstract:

Objective To evaluate the efficacy and safety of Calcipotriol ointment (Cipotriol) in the treatment of psoriasis vulgaris in a multi-center clinical study. Methods A total of 127 patients were randomly divided into group trial (including 64 patients) and group control (63 patients)， treated with Cipotrio and Daivonex respectively ，twice a day for 8 weeks. PASI score and DLQI questionnaire were considered to assess the efficacy after 2, 4 8 weeks’ treatment. Results There were 9 patients totally recovery, 26 patients obviously improved, 19 patients slightly progressed and 10 patients ineffective and the PASI score decreases from 7.87±4.72 to3.74±2.86 after 8 weeks’ Cipotriol treatment in the trial group. No significant differences were observed in the efficacy, effective rate,reduction of PASI（χ2=2.6679, Z = -1.12, χ2 =1.550, P=0.1024, 0.262, 0.2153）and the DLQI assessment between the two groups .Both treatments were safe and well tolerated in which local skin irritations were found 7.8％ in group Cipotriol and 6.3％ in group control. Conclusions Our results demonstrate Calcipotriol ointment (Cipotriol) is effective, safe and well tolerated in the short-term treatment of psoriasis.

Key words: Calcipotriol, psoriasis, PASI, DLQI