Abstract: 【Abstract】 Serofast state in syphilis refers to a special serological reaction in syphilis patients, whose clinical symptoms have disappeared after regular anti-syphilitic treatment, but the non-Treponema pallidum antigen-based serologic test remains positive. Accurate estimation of serofast state in syphilis is important for the avoidance of overtreatment and/or relative undertreatment in clinical practice. In order to further understand the serofast state in syphilis, establish and improve its clinical management strategies, solve clinicians′ doubts about serofast syphilis, and reduce the psychological burden and improve the quality of life of the population with serofast syphilis, the Committee on Sexually Transmitted Diseases, China Dermatologist Association organized relevant Chinese experts to discuss and reach a consensus on the definition, epidemiological features, possible relevant factors and standardized management of serofast state in syphilis.

Key words: Syphilis, Syphilis serodiagnosis, Syphilis serofast, Non-Treponema pallidum antigen serologic test