Chinese Journal of Dermatology ›› 2021, Vol. 54 ›› Issue (6): 545-548.doi: 10.35541/cjd.20190945

• Reviews • Previous Articles     Next Articles

Mechanisms underlying hematogenous dissemination of Treponema pallidum

Chen Senhong1,2, Yang Bin1,2   

  1. 1Department of Dermatology, Guangdong Provincial Dermatology Hospital, Guangzhou 510000, China; 2Graduate College, Guangdong Medical University, Zhanjiang 524000, Guangdong, China
  • Received:2019-09-29 Revised:2020-03-24 Online:2021-06-15 Published:2021-05-31
  • Contact: Yang Bin

Abstract: 【Abstract】 Syphilis is a multisystemic disease caused by hematogenous dissemination of Treponema pallidum after its invasion into the circulation system. However, the specific mechanism of systemic dissemination is not yet fully clear. Based on the research progress in China and other countries, this review discusses mechanisms of hematogenous dissemination of Treponema pallidum in terms of Treponema pallidum adhesion, extracellular matrix degradation, destruction of intercellular connection and cytoskeletal system, angiogenesis, inflammatory cell infiltration, etc., aiming to provide a theoretical basis for further research.

Key words: Syphilis, Treponema pallidum, Blood circulation

CLC Number: 

  • R759.1