Abstract: 【Abstract】 Objective To systematically evaluate the efficacy of benzathine penicillin combined with ceftriaxone on the negative conversion rate of the rapid plasma reagin circle card test/toluidine red unheated serum test （RPR/TRUST） in the treatment of early syphilis. Methods According to the search strategy, online databases （PubMed, Web of science, Embase, Cochrane Library, CNKI, Wanfang and VIP） were searched for case-control studies on benzathine penicillin combined with ceftriaxone in the treatment of early syphilis. The Newcastle Ottawa scale （NOS） was used to evaluate the quality of the included articles, and the RevMan5.3 software to analyze the negative conversion rate of RPR/TRUST. Results A total of 14 case-control studies were included, including 1 160 syphilis patients （585 in the combination treatment group and 575 in the benzathine penicillin alone group）. According to the meta-analysis, the negative conversion rate of serum RPR/TRUST was significantly higher in the combination treatment group than in the benzathine penicillin alone group （OR = 3.70, 95% CI ［2.71, 5.06］, P＜0.001）. Subgroup analysis based on the follow-up duration, the negative conversion rate of serum RPR/TRUST was also significantly higher in the combination treatment group than in the benzathine penicillin alone group after 3-month （OR = 3.68, 95% CI ［2.26, 5.98］, P＜0.001）, 6-month （OR = 3.11, 95% CI ［2.26, 4.27］, P＜0.001） and 12-month treatment （OR = 4.35, 95% CI ［2.81, 6.73］, P＜0.001）. Conclusion Compared with benzathine penicillin, benzathine penicillin combined with ceftriaxone can more effectively promote serum RPR/TRUST to turn negative in the treatment of early syphilis.

Key words: Syphilis, Penicillin G benzathine, Ceftriaxone, Drug therapy, combination, Syphilis serodiagnosis, Meta analysis