Chinese Journal of Dermatology ›› 2021, Vol. 54 ›› Issue (5): 459-462.doi: 10.35541/cjd.20200191

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Risk factors and predictors of neurosyphilis

Li Ke1, Wang Qianqiu2, Long Fuquan1#br#   

  1. 1Department of Sexually Transmitted Disease, Shanghai Skin Disease Hospital, Shanghai 200443, China; 2Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2020-02-28 Revised:2020-07-20 Online:2021-05-15 Published:2021-04-29
  • Contact: Long Fuquan
  • Supported by:
    National Natural Science Foundation of China (81772209); Medical Guidance Project of Shanghai Science and Technology Commission (18411969600); CAMS Innovation Fund for Medical Sciences (2016-I2M-3021)

Abstract: 【Abstract】 Neurosyphilis is a serious clinical stage of syphilis caused by Treponema pallidum invading the nervous system, and risk and predictive factors of neurosyphilis are different between syphilis patients with and without HIV infection. The risk factors for neurosyphilis in HIV-negative patients with syphilis mainly include gender, age, clinical stage of syphilis, treatment, etc.; the predictive factors include serological titers, changes in some indicators of cerebrospinal fluid, neurological or ophthalmic symptoms. HIV viral load, CD4+ T cell counts and antiretroviral treatment are the main predictors and risk factors for neurosyphilis in HIV-positive patients with syphilis.

Key words: Neurosyphilis, Risk factors, HIV, Syphilis serodiagnosis, Predictive factors

CLC Number: 

  • R75