Chinese Journal of Dermatology ›› 2021, Vol. 54 ›› Issue (11): 951-954.doi: 10.35541/cjd.20210522

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Neurosyphilis: current research status and management strategy exploration

Wang Qianqiu1, Du Fangzhi1, Zhang Xu1, Zhang Ruili2   

  1. 1Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College/Department of Clinical Prevention and Control of STD, National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China; 2Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210015, China
  • Received:2021-07-15 Revised:2021-09-23 Online:2021-11-15 Published:2021-11-01
  • Contact: Wang Qianqiu; Zhang Ruili
  • Supported by:
    National Natural Science Foundation of ChinaNational Natural Science Foundation of China;CAMS Innovation Fund for Medical Sciences;Nanjing Incubation Program for National Clinical Research Center

Abstract: 【Abstract】 Neurosyphilis is one of the most serious clinical manifestations of syphilis. In recent years, more and more neurosyphilis cases have been reported in Chinese literature. However, the exact incidence of neurosyphilis is unknown, and there are still some key scientific problems urgent to be solved in clinical diagnosis and treatment, pathogenesis, and prevention and control of neurosyphilis. Therefore, in order to provide a reference for the prevention and treatment of neurosyphilis, this article proposes the CARE-NS strategy, including the following 6 aspects: Comprehensive management including multiple disciplinary treatment(C), Alleviating neurological impairment and sequelae (A), Risk factors and clinical epidemiology (R), Etiology and pathogenesis (E), New diagnostic indicators and strategies (N), Social impact and cost-effectiveness analysis (S).

Key words: Neurosyphilis, Communicable disease control, CARE-NS strategy