Chinese Journal of Dermatology ›› 2023, e20220279.doi: 10.35541/cjd.20220279

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Roles of Langerhans cells in atopic dermatitis

Chen Jincong1, Lin Lihang1, Su Huichun1,2   

  • Received:2022-04-22 Revised:2022-10-09 Online:2023-01-05 Published:2023-07-12
  • Contact: Lin Lihang; Su Huichun;
  • Supported by:
    Natural Science Foundation of Fujian Province of China;The Investigator Initiation Fund Project of Fujian Medical University Union Hospital

Abstract: 【Abstract】 Langerhans cells(LCs) are a kind of important antigen-presenting cells in the epidermis, and are usually divided into 3 subsets: steady-state, activated, and LC-like cells. Atopic dermatitis(AD) is a chronic recurrent inflammatory disease. The latest studies have shown that LCs play important roles in different age stages, pruritus, skin lesion healing, and other aspects in AD. In addition, in different microenvironments of AD, different subpopulations of LCs and LC-like cells play contradictory roles in promoting or inhibiting the inflammation in AD by activating or inhibiting different molecular switches and inflammatory pathways.

Key words: Langerhans cell, Dermatitis, atopic, Pruritus, Age factors, Wound healing