朗格汉斯细胞在特应性皮炎中的研究进展

doi:10.35541/cjd.20220279

Abstract

Abstract: 【Abstract】 Langerhans cells（LCs） are a kind of important antigen-presenting cells in the epidermis, and are usually divided into 3 subsets: steady-state, activated, and LC-like cells. Atopic dermatitis（AD） is a chronic recurrent inflammatory disease. The latest studies have shown that LCs play important roles in different age stages, pruritus, skin lesion healing, and other aspects in AD. In addition, in different microenvironments of AD, different subpopulations of LCs and LC-like cells play contradictory roles in promoting or inhibiting the inflammation in AD by activating or inhibiting different molecular switches and inflammatory pathways.

Key words: Langerhans cell, Dermatitis, atopic, Pruritus, Age factors, Wound healing

Chen Jincong, Lin Lihang, Su Huichun, . Roles of Langerhans cells in atopic dermatitis[J]. Chinese Journal of Dermatology,2023,e20220279. doi:10.35541/cjd.20220279

References ［35］

［1］	Liu X, Zhu R, Luo Y, et al. Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation［J］. Immunity, 2021,54（10）:2305⁃2320.e11. doi: 10.1016/j.immuni.2021.08.012.
［2］	Sheng J, Chen Q, Wu X, et al. Fate mapping analysis reveals a novel murine dermal migratory Langerhans⁃like cell population［J］. Elife, 2021,10. doi: 10.7554/eLife.65412.
［3］	Girolomoni G, Busà V M. Flare management in atopic dermatitis: from definition to treatment［J］. Ther Adv Chronic Dis, 2022,13:364115304.doi: 10.1177/20406223211066728.
［4］	Zhang S, Edwards TN, Chaudhri VK, et al. Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis［J］. Cell, 2021,184（8）:2151⁃2166. doi: 10.1016/j.cell.2021.03.002.
［5］	Becerril⁃García M A, Yam⁃Puc J C, Maqueda⁃Alfaro R, et al. Langerhans cells from mice at birth express endocytic⁃ and pattern recognition⁃receptors, migrate to draining lymph nodes ferrying antigen and activate neonatal T cells in vivo［J］. Front Immunol, 2020,11:744. doi: 10.3389/fimmu.2020.00744.
［6］	Brough HA, Nadeau KC, Sindher SB, et al. Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?［J］. Allergy, 2020,75（9）:2185⁃2205. doi: 10.1111/all.14304.
［7］	Fania L, Moretta G, Antonelli F, et al. Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype⁃specific biomarkers to therapeutic targets［J］. Int J Mol Sci, 2022,23（5）. doi: 10.3390/ijms23052684.
［8］	Matsui K, Shibata R, Mogi K. Influence of the Th1 cytokine environment on CCL5 production from Langerhans cells［J］. Biol Pharm Bull, 2022,45（4）:491⁃496. doi: 10.1248/bpb.b21⁃00985.
［9］	Pilkington SM, Ogden S, Eaton LH, et al. Lower levels of interleukin⁃1β gene expression are associated with impaired Langerhans′ cell migration in aged human skin［J］. Immunology, 2018,153（1）:60⁃70. doi: 10.1111/imm.12810.
［10］	Hasegawa T, Feng Z, Yan Z, et al. Reduction in human epidermal Langerhans cells with age is associated with decline in CXCL14⁃mediated recruitment of CD14（+） monocytes［J］. J Invest Dermatol, 2020,140（7）:1327⁃1334. doi: 10.1016/j.jid.2019.11.017.
［11］	唐玉祺, 刘双飞, 杨泽安, 等. 老年特应性皮炎的诊疗研究进展［J］. 皮肤性病诊疗学杂志, 2021,28（5）:411⁃414. doi: 10. 3969/j.issn.1674－8468.2021.05.018.
［12］	Tang L, Li X, Deng Z, et al. Conjugated linoleic acid attenuates 2,4⁃dinitrofluorobenzene⁃induced atopic dermatitis in mice through dual inhibition of COX⁃2/5⁃LOX and TLR4/NF⁃κB signaling［J］. J Nutr Biochem, 2020,81:108379.doi: 10.1016/j.jnutbio.2020.108379.
［13］	Rajesh A, Wise L, Hibma M. The role of Langerhans cells in pathologies of the skin［J］. Immunol Cell Biol, 2019,97（8）:700⁃713. doi: 10.1111/imcb.12253.
［14］	Miake S, Tsuji G, Takemura M, et al. IL⁃4 augments IL⁃31/IL⁃31 receptor alpha interaction leading to enhanced Ccl 17 and Ccl 22 production in dendritic cells: implications for atopic dermatitis［J］. Int J Mol Sci, 2019,20（16）:4053. doi: 10.3390/ijms2016 4053.
［15］	Cevikbas F, Lerner EA. Physiology and pathophysiology of itch［J］. Physiol Rev, 2020,100（3）:945⁃982. doi: 10.1152/physrev. 00017.2019.
［16］	Yosipovitch G, Berger T, Fassett MS. Neuroimmune interactions in chronic itch of atopic dermatitis［J］. J Eur Acad Dermatol Venereol, 2020,34（2）:239⁃250. doi: 10.1111/jdv.15973.
［17］	Pavel P, Blunder S, Moosbrugger⁃Martinz V, et al. Atopic dermatitis: the fate of the fat［J］. Int J Mol Sci, 2022,23（4）.doi: 10.3390/ijms23042121.
［18］	Szöllősi AG, Oláh A, Lisztes E, et al. Pruritus: a sensory symptom generated in cutaneous immuno⁃neuronal crosstalk［J］. Front Pharmacol, 2022,13:745658. doi: 10.3389/fphar.2022. 745658.
［19］	Deckers J, Hammad H, Hoste E. Langerhans cells: sensing the environment in health and disease［J］. Front Immunol, 2018,9:93. doi: 10.3389/fimmu.2018.00093.
［20］	Ledwon JK, Vaca EE, Huang CC, et al. Langerhans cells and SFRP2/Wnt/beta⁃catenin signalling control adaptation of skin epidermis to mechanical stretching［J］. J Cell Mol Med, 2022,26（3）:764⁃775. doi: 10.1111/jcmm.17111.
［21］	Rajesh A, Stuart G, Real N, et al. Depletion of langerin（+） cells enhances cutaneous wound healing［J］. Immunology, 2020,160（4）:366⁃381. doi: 10.1111/imm.13202.
［22］	Esser⁃von Bieren J. Eicosanoids in tissue repair［J］. Immunol Cell Biol, 2019,97（3）:279⁃288. doi: 10.1111/imcb. 12226.
［23］	Otsuka M, Egawa G, Kabashima K. Uncovering the mysteries of Langerhans cells, inflammatory dendritic epidermal cells, and monocyte⁃derived Langerhans cell⁃like cells in the epidermis［J］. Front Immunol, 2018,9:1768. doi: 10.3389/fimmu.2018. 01768.
［24］	Egawa G, Kabashima K. A new player in the dermis［J］. Elife 2021,10:e68979. doi: 10.7554/eLife.68979.
［25］	Park HH, Lee S, Yu Y, et al. TGF⁃β secreted by human umbilical cord blood⁃derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF⁃α and IgE［J］. Stem cells, 2020,38（7）:904⁃916. doi: 10.1002/stem.3183.
［26］	Strobl H, Krump C, Borek I. Micro⁃environmental signals directing human epidermal Langerhans cell differentiation［J］. Semin Cell Dev Biol, 2019,86:36⁃43. doi: 10.1016/j.semcdb. 2018.02.016.
［27］	Sconocchia T, Del Gaudio I, Meshcheryakova A, et al. Induction of the sphingosine⁃1⁃phosphate signaling pathway by TGF⁃β1 during Langerhans⁃type dendritic cell differentiation［J］. Eur J Immunol, 2021,51（7）:1854⁃1856. doi: 10.1002/eji.202049013.
［28］	Brand A, Diener N, Zahner SP, et al. E⁃cadherin is dispensable to maintain Langerhans cells in the epidermis［J］. J Invest Dermatol, 2020,140（1）:132⁃142. doi: 10.1016/j.jid.2019.06.132.
［29］	Turner CT, Zeglinski MR, Richardson KC, et al. Granzyme B contributes to barrier dysfunction in oxazolone⁃induced skin inflammation through E⁃cadherin and FLG cleavage［J］. J Invest Dermatol, 2021,141（1）: 36⁃47. doi: 10.1016/j.jid.2020.05.095.
［30］	Yeo H, Ahn SS, Lee JY, et al. Disrupting the DNA binding of egr⁃1 with a small⁃molecule inhibitor ameliorates 2,4⁃dinitrochlorobenzene⁃induced skin inflammation［J］. J Invest Dermatol, 2021,141（7）:1851⁃1855. doi: 10.1016/j.jid.2020.12. 029.
［31］	Gratton R, Tricarico PM, Moltrasio C, et al. Pleiotropic role of Notch signaling in human skin diseases［J］. Int J Mol Sci, 2020,21（12）. doi: 10.3390/ijms21124214.
［32］	Marschall P, Wei R, Segaud J, et al. Dual function of Langerhans cells in skin TSLP⁃promoted T（FH） differentiation in mouse atopic dermatitis［J］. J Allergy Clin Immunol, 2021,147（5）:1778⁃1794. doi: 10.1016/j.jaci. 2020.10.006.
［33］	Davies J, Vallejo AF, Sirvent S, et al. An IRF1⁃IRF4 toggle⁃switch controls tolerogenic and immunogenic transcriptional programming in human Langerhans cells［J］. Front Immunol, 2021,12:665312. doi: 10.3389/fimmu. 2021.665312.
［34］	Yu J, Luo Y, Zhu Z, et al. A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor［J］. J Allergy Clin Immunol, 2019,143（6）:2108⁃2119. doi: 10.1016/j.jaci.2018. 11.036.
［35］	Hong C, Lin S, Clausen BE, et al. Selective AhR knockout in langerin⁃expressing cells abates Langerhans cells and polarizes Th2/Tr1 in epicutaneous protein sensitization［J］. Proc Natl Acad Sci U S A, 2020,117（23）:12980⁃12990. doi: 10.1073/pnas.1917479117.

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[3]	Chen Nana, Li Zheng, Zhang Jie, Li Shishen, Li Wei. Early infection status among 147 cases of latent syphilis in Nanning city: a cross-sectional survey [J]. Chinese Journal of Dermatology, 2024, 57(3): 213-217.
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Roles of Langerhans cells in atopic dermatitis

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