Abstract: 【Abstract】 Objective To analyze clinical manifestations, pathological features and prognosis of patients with stage Ⅰ cutaneous melanoma. Methods Clinical data were collected from 163 patients with stage Ⅰ cutaneous melanoma in Department of Dermatology, Xijing Hospital from January 2010 to January 2020, and clinical manifestations, pathological features, treatment methods and prognosis were retrospectively analyzed. Results Among the 163 patients with stage Ⅰ cutaneous melanoma, 56 （34.36%） were males, and 107 （65.64%） were females, with a median age of 53 years at the clinic visit. Primary skin lesions were most frequently located on the extremities in 104 cases （63.80%）, of which 39 presented with lesions on the finger or toe nails and 65 with lesions on the other parts of the extremities; skin lesions were located at sun-exposed sites such as the head and face in 29 （17.79%）cases, and at non-sun-exposed sites such as the trunk and extremities except the hands and feet in 30（18.40%）. Of the 163 patients, 56 （34.36%） were pathologically diagnosed with stage ⅠA cutaneous melanoma, and 107 （65.64%） with stage ⅠB cutaneous melanoma. According to a pathological staging system, 104 （63.80%） patients suffered from acral lentiginous melanoma, 23 （14.11%） superficial spreading melanoma, 15 （9.20%） nodular melanoma, 14 （8.59%） malignant lentigo-maligna melanoma, and 7（4.29%） other rare or difficult-to-determine types. All the 163 patients received surgical treatment at least once, of whom 15 underwent finger or toe amputation, 94 extended resections, and 54 unextended resections; 35 received secondary surgeries, of whom 33 underwent extended resections and 2 finger amputation. Seven patients developed postoperative lymph node and/or distant organ metastases, 2 of whom died after distant organ metastases. The 5-year survival rate of the 163 patients was 98.00%. Conclusion Stage Ⅰ cutaneous melanoma commonly has favorable prognosis, and 7 patients developed postoperative lymph node and/or distant organ metastases in this study, suggesting that long-term follow-up of patients with acral melanoma and early intervention of those with metastatic melanoma should be strengthened.

Key words: Melanoma, Therapy, Prognosis, Clinicopathological features