皮肤疾病光动力治疗的光源和照光参数选择

doi:10.35541/cjd.20200041

Abstract

Abstract: 【Abstract】 Photodynamic therapy （PDT） is the first?line treatment of some intractable skin diseases, such as actinic keratosis, condyloma acuminatum and moderate to severe acne vulgaris. In clinical practice, radiation parameters and light sources are important for the efficacy of PDT. This review focuses on the selection of radiation parameters and light sources for PDT in terms of the wavelength and type of light sources and dose of radiation, and summarizes research progress in new light sources for PDT.

Key words: Photochemotherapy, Skin diseases, Radiation parameters, Light sources

Liu Pei, Shi Lei, Wang Xiuli. Selection of light sources and radiation parameters in photodynamic therapy for skin diseases[J].Chinese Journal of Dermatology, 2021,54(11):1015-1018.

References ［29］

［1］	中华医学会皮肤性病学分会光动力治疗研究中心. 氨基酮戊酸光动力疗法临床应用专家共识［J］. 中华皮肤科杂志, 2015,48（10）:675⁃678. doi: 10.3760/cma.j.issn.0412⁃4030.2015. 10.001.
［2］	Kwiatkowski S, Knap B, Przystupski D, et al. Photodynamic therapy ⁃ mechanisms, photosensitizers and combinations［J］. Biomed Pharmacother, 2018,106:1098⁃1107. doi: 10.1016/j.biopha.2018.07.049.
［3］	Morton CA, Szeimies RM, Basset⁃Séguin N, et al. European Dermatology Forum Guidelines on topical photodynamic therapy 2019 Part 2: emerging indications ⁃ field cancerization, photorejuvenation and inflammatory/infective dermatoses［J］. J Eur Acad Dermatol Venereol, 2020,34（1）:17⁃29. doi: 10.1111/jdv.16044.
［4］	Wong TH, Morton CA, Collier N, et al. British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018［J］. Br J Dermatol, 2019,180（4）:730⁃739. doi: 10.1111/bjd.17309.
［5］	Wang XL, Wang HW, Huang Z, et al. Study of protoporphyrin IX （PpIX） pharmacokinetics after topical application of 5⁃aminolevulinic acid in urethral condylomata acuminata［J］. Photochem Photobiol, 2007,83（5）:1069⁃1073. doi: 10.1111/j.1751⁃1097.2007.00178.x.
［6］	LaRochelle E, Marra K, LeBlanc RE, et al. Modeling PpIX effective light fluence at depths into the skin for PDT dose comparison［J］. Photodiagnosis Photodyn Ther, 2019,25:425⁃435. doi: 10.1016/j.pdpdt.2019.01.022
［7］	Lei TC, Glazner GF, Duffy M, et al. Optical properties of hematoporphyrin monomethyl ether （HMME）, a PDT photosensitizer［J］. Photodiagnosis Photodyn Ther, 2012,9（3）:232⁃242. doi: 10.1016/j.pdpdt.2012.01.003.
［8］	Zhang Y, Zou X, Chen H, et al. Clinical study on clinical operation and post⁃treatment reactions of HMME⁃PDT in treatment of PWS［J］. Photodiagnosis Photodyn Ther, 2017,20:253⁃256. doi: 10.1016/j.pdpdt.2017.09.013.
［9］	Li DC, Nong X, Hu ZY, et al. Efficacy and related factors analysis in HMME⁃PDT in the treatment of port wine stains［J］. Photodiagnosis Photodyn Ther, 2020,29:101649. doi: 10.1016/j.pdpdt.2020.101649.
［10］	Tang Y, Xie H, Li J, et al. The association between treatment reactions and treatment efficiency of Hemoporfin⁃photodynamic therapy on port wine stains: a prospective double blind randomized controlled trial［J］. Photodiagnosis Photodyn Ther, 2017,18:171⁃178. doi: 10.1016/j.pdpdt.2017.02.005.
［11］	Jamali Z, Hejazi SM, Ebrahimi SM, et al. Effects of LED⁃based photodynamic therapy using red and blue lights, with natural hydrophobic photosensitizers on human glioma cell line［J］. Photodiagnosis Photodyn Ther, 2018,21:50⁃54. doi: 10.1016/j.pdpdt.2017.11.002.
［12］	Brancaleon L, Moseley H. Laser and non⁃laser light sources for photodynamic therapy［J］. Lasers Med Sci, 2002,17（3）:173⁃186. doi: 10.1007/s101030200027.
［13］	Etcheverry ME, Pasquale MA, Garavaglia M. Photodynamic therapy of HeLa cell cultures by using LED or laser sources［J］. J Photochem Photobiol B, 2016,160:271⁃277. doi: 10.1016/j.jphotobiol.2016.04.013.
［14］	Michelini M. Photodynamic therapy activated by intense pulsed light in the treatment of actinic keratosis［J］. G Ital Dermatol Venereol, 2020,155（4）:470⁃476. doi: 10.23736/S0392⁃0488. 18.05894⁃7.
［15］	Zhang L, Wu Y, Zhang Y, et al. Topical 5⁃aminolevulinic photodynamic therapy with red light vs intense pulsed light for the treatment of acne vulgaris: a spilit face, randomized, prospective study［J］. Dermatoendocrinol, 2017,9（1）:e1375634. doi: 10.1080/19381980.2017.1375634.
［16］	Requena MB, Vollet Filho JD, Barboza de Nardi A, et al. Topical and intradermal delivery of PpIX precursors for photodynamic therapy with intense pulsed light on porcine skin model［J］. Lasers Med Sci, 2019,34（9）:1781⁃1790. doi: 10.1007/s10103⁃019⁃02771⁃y.
［17］	Hass R, Jacobs R, Kaufmann AM, et al. Sensitization of immune cells following hexylaminolevulinate photodynamic therapy of cervical intraepithelial neoplasia［J］. Photodiagnosis Photodyn Ther, 2017,17:82⁃86. doi: 10.1016/j.pdpdt.2016.11.006.
［18］	Ozog DM, Rkein AM, Fabi SG, et al. Photodynamic therapy: a clinical consensus guide［J］. Dermatol Surg, 2016,42（7）:804⁃827. doi: 10.1097/DSS.0000000000000800.
［19］	Sakamoto FH, Lopes JD, Anderson RR. Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy?［J］. J Am Acad Dermatol, 2010,63（2）:183⁃193; quiz 193⁃194. doi: 10.1016/j.jaad.2009.09.056.
［20］	Morton CA, Braathen LR. Daylight Photodynamic therapy for actinic keratoses［J］. Am J Clin Dermatol, 2018,19（5）:647⁃656. doi: 10.1007/s40257⁃018⁃0360⁃y.
［21］	Ibbotson S, Stones R, Bowling J, et al. A consensus on the use of daylight photodynamic therapy in the UK［J］. J Dermatolog Treat, 2017,28（4）:360⁃367. doi: 10.1080/09546634.2016.1240863.
［22］	Mordon S, Vignion⁃Dewalle AS, Thecua E, et al. Can daylight⁃PDT be performed indoor?［J］. G Ital Dermatol Venereol, 2018,153（6）:811⁃816. doi: 10.23736/S0392⁃0488.18.05907⁃2.
［23］	Larochelle E, Chun HH, Hasan T, et al. Multi⁃spectral wide⁃field imaging for PplX PDT dosimetry of skin［C/OL］//Spie Bios, San Francisco, California, 2016［2020⁃08⁃14］. https://www.spiedigitallibrary.org/conference⁃proceedings⁃of⁃spie/9694/1/Multi⁃spectral⁃wide⁃field⁃imaging⁃for⁃PplX⁃PDT⁃dosimetry⁃of/10.1117/12.2213463.full?SSO=1. doi: 10.1117/12.2213463.
［24］	Attili SK, Lesar A, McNeill A, et al. An open pilot study of ambulatory photodynamic therapy using a wearable low⁃irradiance organic light⁃emitting diode light source in the treatment of nonmelanoma skin cancer［J］. Br J Dermatol, 2009,161（1）:170⁃173. doi: 10.1111/j.1365⁃2133.2009.09096.x.
［25］	Mordon S, Cochrane C, Tylcz JB, et al. Light emitting fabric technologies for photodynamic therapy［J］. Photodiagnosis Photodyn Ther, 2015,12（1）:1⁃8. doi: 10.1016/j.pdpdt.2014.11. 002.
［26］	Masuda H, Kimura M, Nishioka A, et al. Dual wavelength 5⁃aminolevulinic acid photodynamic therapy using a novel flexible light⁃emitting diode unit［J］. J Dermatol Sci, 2019,93（2）:109⁃115. doi: 10.1016/j.jdermsci.2018.12.006.
［27］	Lucky SS, Soo KC, Zhang Y. Nanoparticles in photodynamic therapy［J］. Chem Rev, 2015,115（4）:1990⁃2042. doi: 10.1021/cr5004198.
［28］	Liu P, Yang W, Shi L, et al. Concurrent photothermal therapy and photodynamic therapy for cutaneous squamous cell carcinoma by gold nanoclusters under a single NIR laser irradiation［J］. J Mater Chem B, 2019,7（44）:6924⁃6933. doi: 10.1039/c9tb01573f.
［29］	Shi L, Liu P, Wu J, et al. The effectiveness and safety of X⁃PDT for cutaneous squamous cell carcinoma and melanoma［J］. Nanomedicine （Lond）, 2019,14（15）:2027⁃2043. doi: 10.2217/nnm⁃2019⁃0094.

[1]	Zhang Guoyi, Gong Xiangdong, Zhu Bokun, Liu Chuanxia, Jing Linghua, Xu Jinyu. Patterns of skin diseases among outpatients attending Hospital of Dermatology of Chinese Academy of Medical Sciences in 2019 [J]. Chinese Journal of Dermatology, 2022, 55(2): 150-152.
[2]	Jiang Peiyu, Zhang Jiawen, Liu Zijing, Wang Xiaoyan, Liu Yunyi, Liu Yixuan, Xu Yang. Basic principles of photobiomodulation and its application in dermatology [J]. Chinese Journal of Dermatology, 2022, 55(1): 84-87.
[3]	Chinese Society of Dermatology, China Dermatologist Association. Consensus on the diagnosis and treatment of autoimmune subepidermal bullous diseases （2022） [J]. Chinese Journal of Dermatology, 2022, 55(1): 1-11.
[4]	Long Hai, Jiang Li, Qiu Yueqi, Yao Nan, Liu Licong, Xie Yuming, Xiong Feng, Tan Siqi, Kuang Qiqi, You Ruixuan, Chai Ke, Luo Xin, Long Haojun, Xin Yue, Guo Ziyu, Wang Jiaqi, Tan Yixin, Zhang Qing, Zhang Guiying, Li Yaping, Su Yuwen, Xiao Rong, Lu Qianjin, . Clinical analysis of 1 057 patients with critical illnesses in a dermatological ward [J]. Chinese Journal of Dermatology, 2021, 54(9): 790-797.
[5]	Autoimmune Disease Group, China Dermatologist Association. Chinese expert consensus on cyclophosphamide for the treatment of autoimmune dermatoses [J]. Chinese Journal of Dermatology, 2021, 54(9): 765-770.
[6]	Hu Feng, Chen Liuqing, Wang Wei, Zheng Fang. Epidemiological characteristics and disease spectrum analysis of outpatients in the dermatology department of a hospital in Wuhan during the COVID-19 epidemic [J]. Chinese Journal of Dermatology, 2021, 54(8): 719-722.
[7]	Ying Jieya, Xiang Wenzhong, Song Xiuzu. Metabolic syndrome and skin diseases [J]. Chinese Journal of Dermatology, 2021, 54(7): 642-645.
[8]	Committee on Autoimmune Diseases, China Dermatologist Association. Expert consensus on methotrexate in the treatment of immune-associated dermatoses [J]. Chinese Journal of Dermatology, 2021, 54(5): 382-390.
[9]	Hu Yanyan, Jiang Qian, Chen Liuqing, Li Dongsheng. Application of reflectance confocal microscopy in the evaluation of clinical efficacy of hemoporfin-mediated photodynamic therapy for purple-type port-wine stain [J]. Chinese Journal of Dermatology, 2021, 54(4): 342-346.
[10]	Ye Ruixian, Xue Rujun, Liang Jingyao, Liu Huanyan, Xiong Qiying, Dong Liangjiao, Zhang Xibao. Role of microRNAs in inflammatory skin diseases [J]. Chinese Journal of Dermatology, 2021, 54(2): 178-182.
[11]	Zhu Beibei, Li Jing, Huang Huiyao, Li Ning, Liu Lijun, Zhang Lihua, Huan Jing, Ni Qi, Hou Wei, Liu Yi, Yang Xueyuan. Analysis of clinical trials of dermatological drugs in China, 2020 [J]. Chinese Journal of Dermatology, 2021, 54(11): 1001-1004.
[12]	Zheng Yucan, Kong Guiping, Jin Yu, Li Mei. A case of hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis caused by a mutation in the FAM111B gene [J]. Chinese Journal of Dermatology, 2021, 54(11): 973-977.
[13]	Zheng Zhe, Zhang Guolong, Wang Peiru, Ji Jie, Wang Xiuli, . Changes in immune cell subsets in cutaneous squamous cell carcinoma tissues from SKH-1 mouse models after aminolevulinic acid-based photodynamic therapy [J]. Chinese Journal of Dermatology, 2021, 54(11): 978-983.
[14]	Jin Shuang, Huang Dan, Chen Kun. Daylight photodynamic therapy for the treatment of actinic keratosis [J]. Chinese Journal of Dermatology, 2021, 54(11): 1023-1027.
[15]	Chen Wei, Xie Heng, Li Li. Extracellular vesicles in dermatology: updates and prospects [J]. Chinese Journal of Dermatology, 2021, 54(10): 910-914.

Selection of light sources and radiation parameters in photodynamic therapy for skin diseases

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［29］

Related Articles 15

Metrics

Comments

Recommended 10