中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (2): 82-83.

• 论著 • 上一篇    下一篇

银屑病患者白细胞流变性和白细胞CD18表达及血清sICAM-1浓度的变化

刘成玉1, 王桂芝2, 谭润鸾1   

  1. 1. 青岛医学院诊断学教研室 266021;
    2. 青岛医学院皮肤病研究所 266021
  • 收稿日期:1997-03-17 修回日期:1997-11-18 出版日期:1998-04-15 发布日期:1998-04-15

The Changes of Leukocyte Rheology, Expression of Leukocyte CD18 and the Concentration of Serum Soluble Intercellular Adhesion Molecule-1 in Patients with Psoriasis

Liu Chengyu1, Wang Guizhi2, Tan Runluan1   

  1. Department of Diagnostics, Qingdao Medical College, Qingdao 266021
  • Received:1997-03-17 Revised:1997-11-18 Online:1998-04-15 Published:1998-04-15

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摘要： 目的 探讨白细胞流变性和细胞粘附分子(CAMS)表达与银屑病的关系。方法 采用ELISA法、红细胞变形能力测定仪和体外血栓血小板粘附两用仪检测了115例银屑病患者和89例健康人白细胞CD18表达、血清可溶性细胞间粘附分子-1(sICAM-1)浓度、白细胞滤过指数(LFI)和白细胞粘附率(LAR)的变化。结果 银屑病患者白细胞CD18表达、sICAM-1浓度、LFI和LAR均明显增高,与对照组比较差异均有显著性,且随着银屑病皮损加重,各指标增高逐渐明显。银屑病患者LFI、LAR与白细胞CD18表达和sICAM-1浓度呈正相关,LFI与LAR呈正相关。结论 白细胞流变性异常和细胞粘附分子表达增高与银屑病发病及皮损严重程度有关。

关键词: 银屑病, 细胞粘着分子, 白细胞流变性

Abstract: Objective To explore the correlation between the leukocyte rheology, cell adhesion molecule(CAM) expression and psoriasis. Methods Enzyme linked immunosorbent assay(ELISA), erythrocyte deformability apparatus and in vitro thrombus and platelet adhesion dual-purpose apparatus were used to determine the changes of leukocyte CD18 expression, levels of serum soluble intercelular adhesion molecule-1(sICAM-1), and the changes of leukocyte filtration index(LFI) and leukocyte adhesion rate(LAR). Results The leukocyte CD18 expression, sICAM-1 level, LFI and LAR were significantly increased in patients with psoriasis than those in controls(P<0.01), and along with the exacerbation of psoriatic skin lesions all the above parameters increased (P<0.01). The LFI and LAR in the patients were positively correlated to the expression of leukocyte CD18 and the sICAM-1 concentration (r=0.718, 0.669, 0.626, 0.680, P<0.01), LFI was positively correlated to LAR (r=0.588, P<0 01). Conclusion These results indicated that the abnormalities of leukocyte rheology and the increase of CAMs expression were closely related to the pathogenesis of psoriasis and the severity of psoriatic skin lesions.

Key words: Psoriasis, Cell adhesion molecules, Leukocyte rheology