中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (2): 79-81.

• 论著 • 上一篇    下一篇

银屑病患者皮损及非皮损部位粘附分子免疫组化研究

蔡绥勍, 孙国均, 郑敏   

  1. 浙江医科大学附属第二医院皮肤科, 杭州 310009
  • 收稿日期:1997-01-02 修回日期:1997-11-14 出版日期:1998-04-15 发布日期:1998-04-15

Immunohistochemical Study of Vascular Endothelium Adhesion Molecules in Psoriatic and Non-psoriatic Skin

Cai Suiqing, Sun Guojun, Zheng Min   

  1. Department of Dermatology, The Second Affiliated Hospital of Zhejiang Medical University, Hangzhou 310009
  • Received:1997-01-02 Revised:1997-11-14 Online:1998-04-15 Published:1998-04-15

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摘要： 目的 为了更好地了解浸润T淋巴细胞和内皮细胞粘附分子的原位表达在银屑病皮损中的相互关系。方法 采用免疫组化染色方法研究银屑病皮损部位和非皮损部位的浸润T淋巴细胞亚群和内皮细胞粘附分子(ICAM-1,ELAM-1,VCAM-1)的原位表达情况。结果 银屑病患者皮损部位T细胞亚群和内皮细胞粘附分子的原位表达均显著高于非皮损部位,而且浸润T淋巴细胞亚群的细胞密度和内皮细胞粘附分子的原位表达程度呈显著正相关。与正常人相比,银屑病非皮损部位和经外用皮质类固醇激素治疗后外观正常的皮肤内皮粘附分子仍呈上调表达。结论 银屑病患者皮肤真皮血管内皮细胞粘附分子的异常上调表达是造成银屑病复发的原因之一。

关键词: 银屑病, 血管内皮, 细胞, 细胞粘附分子, T淋巴细胞

Abstract: Objective To study the relationship between the in situ expression of infiltrating T lymphocyte subsets and leukocyte adhesion molecules in psoriatic patients. Methods Immunohistochemical technique was employed to study the expression of infiltrating T lymphocyte subsets (CD3, CD4, CD8) and leukocyte adhesion molecules (ICAM-1, ELAM-1, VCAM-1) in the lesional and non lesional psoriatic skin. Results There was a significant increase of T lymphocyte subsets (CD3, CD4 and CD8) and adhesion molecules (ICAM-1, ELAM-1, VCAM-1) in the lesional skin than those in non lesional skin in psoriasis, and that there is a significant positive correlation between the density of infiltrating T lymphocyte subsets and the intensity of in situ expression of adhesion molecules. In comparison to the materials from normal controls, the upregulation expression of adhesion molecules was observed in non-lesional skin and normal appearance skin after short duration topical treatment with corticosteroid. Conclusion Increased upregulation expression of adhesion molecules is closely associated with the infiltration of T lymphocytes in lesional skin of psoriasis and may be one of the factors for the recurrence of psoriasis.

Key words: Psoriasis, Cells,endothelium vascular, Cell adhesion molecules, T lymphocytes